Olfr988 Activators
Olfr988 is an olfactory receptor, part of the G-protein-coupled receptor (GPCR) family, playing a crucial role in the detection and interpretation of olfactory signals. These receptors are essential in the olfactory system, converting chemical stimuli into electrical signals that are processed by the brain, enabling the perception of odors. The activation of Olfr988, like other olfactory receptors, hinges on the specific binding of odorant molecules to the receptor. This binding induces conformational changes in Olfr988, which are critical for initiating downstream intracellular signaling pathways. Upon ligand binding, Olfr988 undergoes a change in structure, facilitating its interaction with G-proteins. This interaction leads to the activation of adenylate cyclase, an enzyme responsible for converting ATP into cyclic AMP (cAMP). Elevated levels of cAMP activate protein kinase A (PKA), which phosphorylates various targets within the cell, culminating in a neuronal response. This signal transduction pathway is fundamental to the olfactory system, enabling the detection and differentiation of an array of odors. The specificity of ligand-receptor interactions, as demonstrated by Olfr988 and its activators, is key to the complex and nuanced nature of olfactory perception. Each receptor, tuned to specific molecular features of odorants, contributes to the vast repertoire of detectable odors.
Understanding the activation mechanisms of receptors like Olfr988 provides valuable insights into sensory biology and GPCR signaling. This knowledge is not only crucial for comprehending the molecular basis of smell but also has broader implications in physiology and pharmacology, as GPCRs are targets for various interventions. However, the primary focus here is on the basic science of olfactory reception and the specific activation mechanisms of Olfr988. This perspective is central to advancing our understanding of sensory systems and their role in interpreting the external environment.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ethyl butyrate | 105-54-4 | sc-214986 sc-214986A | 1 kg 4 kg | $100.00 $210.00 | ||
Ethyl butyrate activates Olfr988 by binding to its orthosteric site, causing a conformational change that facilitates G-protein coupling. This leads to adenylate cyclase stimulation, increasing cyclic AMP levels, and activating PKA, functionally activating Olfr988. | ||||||
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $107.00 $225.00 | ||
Isopentyl acetate activates Olfr988 by binding to specific sites on the receptor, causing a conformational rearrangement. This rearrangement facilitates G-protein interaction and adenylate cyclase activation, increasing cyclic AMP production, leading to PKA activation and functional activation of Olfr988. | ||||||
Linalool | 78-70-6 | sc-250250 sc-250250A sc-250250B | 5 g 100 g 500 g | $47.00 $72.00 $110.00 | ||
Linalool activates Olfr988 through allosteric modulation, altering its conformation to enable effective G-protein coupling. This stimulates adenylate cyclase, elevating cyclic AMP levels, and activating PKA, thereby functionally activating Olfr988. | ||||||
(±)-beta-Citronellol | 106-22-9 | sc-294094 sc-294094A | 25 ml 500 ml | $32.00 $156.00 | ||
Citronellol activates Olfr988 by interacting with its ligand-binding domain, causing a structural change. This change leads to G-protein activation and adenylate cyclase stimulation, resulting in increased cyclic AMP levels and PKA activation, functionally activating Olfr988. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $32.00 $62.00 $218.00 | 2 | |
Eugenol activates Olfr988 by binding directly to the receptor, inducing a conformational change. This stimulates the G-protein signaling pathway, leading to adenylate cyclase activation, increased cyclic AMP levels, and subsequent PKA activation, thereby functionally activating Olfr988. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $45.00 $119.00 | ||
Geraniol activates Olfr988 through its interaction with specific binding sites, inducing structural alterations. These alterations facilitate G-protein coupling, leading to adenylate cyclase stimulation, increased cyclic AMP production, and PKA activation, functionally activating Olfr988. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral activates Olfr988 through allosteric modulation, altering the receptor's conformation. This alteration leads to G-protein coupling and activation, stimulating adenylate cyclase, increasing cyclic AMP levels, and activating PKA, thereby functionally activating Olfr988. | ||||||
Ethyl hexanoate | 123-66-0 | sc-235049 | 5 ml | $51.00 | ||
Ethyl hexanoate activates Olfr988 by binding to its orthosteric site, inducing a conformational change in the receptor. This leads to G-protein coupling, adenylate cyclase activation, increased cyclic AMP production, and PKA activation, functionally activating Olfr988. | ||||||
Heptaldehyde | 111-71-7 | sc-250089 sc-250089A | 2 ml 100 ml | $30.00 $59.00 | ||
Heptaldehyde activates Olfr988 through direct interaction with its binding domain, triggering a structural change. This change enables G-protein coupling and adenylate cyclase activation, increasing cyclic AMP production and PKA activation, thereby functionally activating Olfr988. | ||||||
Octanal | 124-13-0 | sc-250612 sc-250612A | 25 ml 100 ml | $26.00 $34.00 | ||
Octanal activates Olfr988 by interacting with specific binding sites on the receptor, leading to a conformational shift. This shift facilitates G-protein coupling and activation, triggering adenylate cyclase, increasing cyclic AMP levels, and activating PKA, functionally activating Olfr988. | ||||||