Olfr935 Activators
Olfr935 is an olfactory receptor, belonging to the family of G protein-coupled receptors (GPCRs), which are pivotal in the detection of odorants and the subsequent olfactory perception. The activation of Olfr935, like other olfactory receptors, involves the binding of specific chemicals, known as odorants, which leads to a series of cellular and molecular events essential for the perception of smell. Upon the binding of an activator to Olfr935, a conformational change occurs in the receptor, initiating a cascade of intracellular events. This cascade typically involves the activation of a G protein, which in turn stimulates adenylyl cyclase, an enzyme responsible for converting ATP to cyclic AMP (cAMP). The increase in cAMP levels is a crucial step in the signaling pathway, as it activates protein kinase A (PKA). PKA phosphorylates various target proteins, leading to changes in cellular function and ultimately resulting in the generation of a nerve impulse. This impulse is transmitted to the brain, where it is interpreted as a specific smell.
The specificity of Olfr935 activation is determined by the structural compatibility between the receptor and the activating chemicals. Each chemical activator has a unique molecular structure that allows it to bind specifically to Olfr935, initiating the receptor's activation. This specificity is critical for the accurate perception of smells, as it allows the olfactory system to distinguish between a vast array of different odorants. The diversity of activators for Olfr935, ranging from floral to woody scents, reflects the receptor's role in detecting a broad spectrum of smells. Understanding the mechanisms of activation of olfactory receptors like Olfr935 is fundamental to comprehending the complex nature of olfactory signaling. It sheds light on how different smells are detected and discriminated, and how the olfactory system contributes to various physiological and behavioral responses. The study of receptors like Olfr935 continues to be a vital area of research in neurobiology and sensory sciences.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Hexyl acetate | 142-92-7 | sc-215149 sc-215149A | 25 ml 500 ml | $32.00 $57.00 | ||
Hexyl acetate activates Olfr935 by binding to the receptor and initiating a G protein-coupled receptor (GPCR) signaling pathway. This activation stimulates adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels. The elevated cAMP activates protein kinase A (PKA), which is crucial for the functional activation and signaling transduction of Olfr935 in olfactory sensory neurons. | ||||||
Linalool | 78-70-6 | sc-250250 sc-250250A sc-250250B | 5 g 100 g 500 g | $47.00 $72.00 $110.00 | ||
Linalool, a floral-scented compound, activates Olfr935 by directly interacting with the receptor. This interaction triggers GPCR signaling, leading to the activation of adenylyl cyclase and a subsequent rise in intracellular cAMP levels. These increased cAMP levels are key for the functional activation of Olfr935, playing a significant role in olfactory perception and signal transduction. | ||||||
(±)-beta-Citronellol | 106-22-9 | sc-294094 sc-294094A | 25 ml 500 ml | $32.00 $156.00 | ||
Citronellol, known for its rose-like aroma, activates Olfr935 by binding to the receptor and initiating GPCR-mediated signaling. This leads to an increase in adenylyl cyclase activity, which elevates cAMP production. The elevated cAMP is essential for the functional activation of Olfr935, enhancing its role in olfactory signal transduction. | ||||||
α-Pinene | 80-56-8 | sc-233784 sc-233784A | 5 ml 250 ml | $52.00 $115.00 | 2 | |
Alpha-Pinene, a compound found in pine oil, activates Olfr935 through its interaction with the receptor, triggering GPCR signaling. This activation stimulates adenylyl cyclase, increasing cAMP levels. The rise in cAMP is crucial for the functional activation of Olfr935, facilitating its role in the detection and discrimination of pine-related odors. | ||||||
Geranyl acetate | 105-87-3 | sc-235243 | 25 g | $41.00 | ||
Geranyl acetate, with a floral and fruity aroma, activates Olfr935 by binding to the receptor, leading to GPCR signaling. This signaling pathway results in the activation of adenylyl cyclase and an increase in cAMP production. Elevated cAMP levels are vital for the functional activation of Olfr935, contributing to its role in olfactory perception. | ||||||
cis-3,7-Dimethyl-2,6-octadien-1-ol | 106-25-2 | sc-234382 | 5 ml | $51.00 | ||
cis-3,7-Dimethyl-2,6-octadien-1-ol, a compound with a sweet rose odor, activates Olfr935 by directly interacting with the receptor, inducing GPCR signaling. This leads to increased adenylyl cyclase activity and a subsequent rise in cAMP levels. The increased cAMP levels are essential for the functional activation of Olfr935, playing a pivotal role in the olfactory signaling process. | ||||||
2-Phenylethanol | 60-12-8 | sc-238198 | 250 ml | $69.00 | ||
2-Phenylethanol, possessing a floral scent, activates Olfr935 by binding to it, initiating GPCR-mediated signaling. This activation results in the stimulation of adenylyl cyclase, leading to a rise in cAMP levels. Elevated cAMP is crucial for the functional activation of Olfr935, enhancing its role in the detection of floral odors. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral, known for its lemon scent, activates Olfr935 by interacting with the receptor and triggering a GPCR-mediated signaling cascade. This cascade results in the activation of adenylyl cyclase, increasing cAMP production. Elevated cAMP levels are crucial for the functional activation of Olfr935, facilitating its role in olfactory perception. | ||||||
(−)-trans-Caryophyllene | 87-44-5 | sc-251281 sc-251281A sc-251281B sc-251281C | 1 ml 5 ml 25 ml 1 L | $81.00 $160.00 $446.00 $2918.00 | 1 | |
(-)-trans-Caryophyllene, with a woody-spicy aroma, activates Olfr935 through its interaction with the receptor, inducing GPCR signaling. This leads to increased adenylyl cyclase activity and a subsequent rise in cAMP levels. Elevated cAMP levels are critical for the functional activation of Olfr935, playing a significant role in olfactory perception. | ||||||
Farnesol | 4602-84-0 | sc-204748 sc-204748A | 50 ml 100 ml | $281.00 $374.00 | 2 | |
Farnesol, possessing a floral and woody scent, activates Olfr935 by binding to the receptor and triggering GPCR signaling. This activation stimulates adenylyl cyclase, increasing cAMP production. The increased cAMP levels are essential for the functional activation of Olfr935, contributing to its role in the detection of floral and woody odors. | ||||||