Olfr800 Inhibitors
Olfr800 is a member of the olfactory receptor family, expressed on the surface of olfactory sensory neurons within the nasal epithelium. Its primary function is to detect and transduce chemical signals from odorants into electrical signals, which are then transmitted to the brain, enabling us to perceive a wide range of scents and odors in our environment. The olfaction process begins with Olfr800 binding to specific odorant molecules, initiating a series of intracellular events that involve the activation of G-proteins and the generation of cyclic adenosine monophosphate (cAMP). These events lead to the depolarization of olfactory sensory neurons, resulting in action potentials that are conveyed to the brain for odor perception. Olfr800's role is essential for our ability to distinguish and interpret various smells.
Inhibition of Olfr800 can occur through both direct and indirect mechanisms, as exemplified by the list of chemicals provided earlier. Direct inhibitors, such as Cisplatin, form covalent bonds with olfactory receptors, interfering with their function and reducing Olfr800's sensitivity to odorants. Indirect inhibitors, on the other hand, disrupt cellular processes in olfactory neurons, leading to damage and indirectly impairing Olfr800's sensitivity. Understanding Olfr800 and its inhibition provides insights into the intricate mechanisms underlying our sense of smell and its potential applications in sensory research.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin directly inhibits Olfr800 by forming covalent bonds with olfactory receptors, interfering with their function and reducing Olfr800's sensitivity to odorants. | ||||||
Silver nitrate | 7761-88-8 | sc-203378 sc-203378A sc-203378B | 25 g 100 g 500 g | $114.00 $378.00 $1081.00 | 1 | |
Silver Nitrate indirectly inhibits Olfr800 by precipitating proteins in olfactory neurons, causing cellular damage, and indirectly impairing Olfr800's sensitivity. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc Chloride indirectly inhibits Olfr800 by modulating olfactory neuron membrane potential, indirectly reducing Olfr800 activity, and affecting the olfaction process. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
Hydrogen Peroxide indirectly inhibits Olfr800 by generating oxidative stress, leading to cellular damage in olfactory neurons and indirectly disrupting Olfr800 function. | ||||||
Ammonium sulfide solution | 12135-76-1 | sc-214536 sc-214536A | 25 ml 500 ml | $73.00 $223.00 | 1 | |
Ammonium Sulfide indirectly inhibits Olfr800 by altering the pH environment in olfactory neurons, indirectly reducing Olfr800 activity, and interfering with olfaction. | ||||||
Ethylene glycol | 107-21-1 | sc-257515 sc-257515A | 500 ml 1 L | $85.00 $120.00 | 1 | |
Ethylene Glycol indirectly inhibits Olfr800 by affecting olfactory neuron membrane properties, indirectly reducing Olfr800 activity, and disrupting the olfaction process. | ||||||
Sodium Fluoride | 7681-49-4 | sc-24988A sc-24988 sc-24988B | 5 g 100 g 500 g | $40.00 $46.00 $100.00 | 26 | |
Sodium Fluoride indirectly inhibits Olfr800 by modulating olfactory neuron membrane potential, indirectly reducing Olfr800 activity, and affecting the olfaction process. | ||||||
FCM Fixation buffer (10X) | sc-3622 | 10 ml @ 10X | $62.00 | 16 | ||
FCM Fixation buffer (10X) indirectly inhibits Olfr800 by forming adducts with cellular molecules in olfactory neurons, leading to damage and indirectly disrupting Olfr800 function. | ||||||
Arsenic(III) oxide | 1327-53-3 | sc-210837 sc-210837A | 250 g 1 kg | $89.00 $228.00 | ||
Arsenic(III) oxide indirectly inhibits Olfr800 by disrupting cellular processes in olfactory neurons, leading to damage and indirectly impairing Olfr800's sensitivity. | ||||||