Olfr734 Inhibitors
Olfr734, a member of the olfactory receptor family 4 subfamily M (OR4M), is a critical component of the human olfactory system, responsible for the remarkable ability to perceive and distinguish various odors. Olfactory receptors, including Olfr734, belong to the class of G-protein-coupled receptors (GPCRs), which are characterized by a seven-transmembrane domain structure. These receptors are primarily expressed in sensory neurons located within the nasal cavity and are vital for the initiation of neuronal responses upon encountering odorant molecules. Olfr734's role in this complex process is to act as a molecular sensor, capable of recognizing specific odorants and triggering the appropriate neuronal signals, ultimately resulting in the perception of distinct smells. The olfactory receptor gene family, to which Olfr734 belongs, constitutes one of the largest gene families in the human genome, highlighting the remarkable diversity and complexity of odorant recognition.
Inhibition of Olfr734 is a nuanced process that can be achieved through various mechanisms. It involves the interference with Olfr734's ability to respond to specific odorants, either directly or indirectly. Direct inhibition occurs when certain chemical compounds bind directly to Olfr734, thereby preventing the receptor from recognizing its intended odorant molecules. This interference leads to disruptions in the initiation of neuronal responses, altering the perception of odors. On the other hand, indirect inhibition involves the modulation of intracellular signaling pathways associated with Olfr734. These pathways play a crucial role in transmitting signals from the receptor to the brain, influencing the overall response to odorants. Chemicals that indirectly inhibit Olfr734 can target specific components of these pathways, such as enzymes or receptors, to modify the receptor's sensitivity to odorants. By elucidating the mechanisms of Olfr734 inhibition, we gain a deeper understanding of the intricate processes underlying olfaction.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cinnamic Aldehyde | 104-55-2 | sc-294033 sc-294033A | 100 g 500 g | $102.00 $224.00 | ||
Cinnamaldehyde is a direct inhibitor of Olfr734, binding directly to the receptor and interfering with the recognition of specific odorant molecules. This direct interference disrupts the initiation of neuronal responses responsible for the perception of cinnamon-like scents. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is an indirect inhibitor that inhibits phosphodiesterases (PDEs), leading to increased cAMP levels and potentially influencing Olfr734's responses to odorants through alterations in the cAMP-dependent signaling pathway. | ||||||
Acetophenone | 98-86-2 | sc-239189 | 5 g | $20.00 | ||
Acetophenone is a direct inhibitor of Olfr734, capable of binding to the receptor and preventing the recognition of specific odorant molecules. This direct interference disrupts the initiation of neuronal responses responsible for the perception of almond-like scents. | ||||||
Suramin sodium | 129-46-4 | sc-507209 sc-507209F sc-507209A sc-507209B sc-507209C sc-507209D sc-507209E | 50 mg 100 mg 250 mg 1 g 10 g 25 g 50 g | $149.00 $210.00 $714.00 $2550.00 $10750.00 $21410.00 $40290.00 | 5 | |
Suramin is an indirect inhibitor that can block purinergic receptors and modulate Olfr734's function through interference with purinergic signaling pathways, potentially altering sensory perception of odors. | ||||||
Ethyl butyrate | 105-54-4 | sc-214986 sc-214986A | 1 kg 4 kg | $100.00 $210.00 | ||
Ethyl Butyrate is a direct inhibitor of Olfr734, binding directly to the receptor and interfering with the recognition of specific odorant molecules. This direct interference disrupts the initiation of neuronal responses responsible for the perception of fruity scents. | ||||||
SQ 22536 | 17318-31-9 | sc-201572 sc-201572A | 5 mg 25 mg | $93.00 $356.00 | 13 | |
SQ 22536 is an indirect inhibitor that inhibits adenylyl cyclase, leading to decreased cAMP levels and potentially influencing Olfr734's responses to odorants through alterations in the cAMP-dependent signaling pathway. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $31.00 $61.00 $214.00 | 2 | |
Eugenol is a direct inhibitor of Olfr734, capable of binding to the receptor and preventing the recognition of specific odorant molecules. This direct interference disrupts the initiation of neuronal responses responsible for the perception of clove-like scents. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $27.00 $52.00 | 37 | |
2-APB is an indirect inhibitor that can block IP3 receptors, leading to decreased intracellular calcium levels and potentially influencing Olfr734's responses to odorants through alterations in calcium signaling pathways. | ||||||
Isovaleric acid | 503-74-2 | sc-250205 | 100 ml | $28.00 | ||
Isovaleric Acid is a direct inhibitor of Olfr734, binding directly to the receptor and interfering with the recognition of specific odorant molecules. This direct interference disrupts the initiation of neuronal responses responsible for the perception of sweaty, cheesy scents. | ||||||
Hexanal | 66-25-1 | sc-252885 | 2 ml | $26.00 | ||
Hexanal is a direct inhibitor of Olfr734, capable of binding to the receptor and preventing the recognition of specific odorant molecules. This direct interference disrupts the initiation of neuronal responses responsible for the perception of green apple-like scents. | ||||||