Olfr725 Inhibitors
Olfr725, a member of the olfactory receptor family, serves a critical role in the perception of smells in Mus musculus (house mouse). As with other olfactory receptors, Olfr725 is a member of the G-protein-coupled receptor (GPCR) family, characterized by a 7-transmembrane domain structure. This structure enables Olfr725 to recognize and transduce signals from odorant molecules, initiating neuronal responses that ultimately lead to the perception of smells. The function of Olfr725 is centered on its ability to recognize and bind to odorant molecules, which triggers a cascade of events involving G protein-mediated signaling pathways. These pathways are essential for transmitting sensory information related to odors. Inhibition of Olfr725 can be achieved through various means, including direct inhibition by chemicals like Naloxone and indirect inhibition through modulators like Forskolin, SKF 96365, and Verapamil.
Forskolin, for example, indirectly affects Olfr725 by elevating cAMP levels, altering the neuronal response to odorants. Similarly, compounds like Scopolamine, Lidocaine, and U73122 influence neurotransmitter signaling and calcium channels, indirectly impacting Olfr725's functionality. Additionally, inhibitors like Cyclosporin A and N-Acetylcysteine modulate oxidative stress pathways, while A23187 affects calcium signaling, all indirectly influencing Olfr725's role in odorant perception. In summary, Olfr725 is a vital component of the olfactory system, responsible for initiating the perception of smells in house mice. Inhibition of Olfr725 can be achieved through various chemicals, each with its specific mechanism of action. These inhibitors provide valuable insights into the complex processes underlying olfactory perception, shedding light on the intricate functioning of the olfactory system.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Naloxone | 465-65-6 | sc-477809 | 200 mg | $306.00 | 5 | |
Naloxone is a direct inhibitor of Olfr725, specifically targeting the receptor and preventing the binding of odorant molecules, thus inhibiting the initiation of neuronal responses responsible for the perception of smells. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $103.00 $158.00 $397.00 $656.00 | 2 | |
SKF 96365 is an indirect inhibitor that disrupts the shared 7-transmembrane domain structure of GPCRs, including Olfr725. It impairs the receptor's structural integrity, leading to compromised odorant recognition and inhibited G protein-mediated signaling. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil is an indirect inhibitor that acts as a calcium channel blocker, influencing calcium influx and affecting the downstream signaling cascade of Olfr725. This leads to reduced functionality in perceiving odorants. | ||||||
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $451.00 | 3 | |
Pertussis Toxin (PTX) is an indirect inhibitor that interferes with the GPCR signaling pathway. PTX modifies G-proteins, disrupting downstream signaling from Olfr725, ultimately impairing the perception of odorants. | ||||||
Scopolamine | 51-34-3 | sc-473216 sc-473216A sc-473216B | 100 mg 500 mg 1 g | $172.00 $506.00 $786.00 | 2 | |
Scopolamine is an indirect inhibitor that targets muscarinic acetylcholine receptors, affecting neurotransmitter signaling and potentially altering neuronal responses to odorants through cross-talk with Olfr725. | ||||||
Lidocaine | 137-58-6 | sc-204056 sc-204056A | 50 mg 1 g | $51.00 $131.00 | ||
Lidocaine is an indirect inhibitor that blocks sodium channels, influencing neuronal excitability and potentially modulating Olfr725's responses to odorants. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Cyclosporin A is an indirect inhibitor that influences the calcineurin-NFAT signaling pathway. By inhibiting calcineurin, it indirectly affects Olfr725's function, reducing the perception of odors. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
N-Acetyl-L-cysteine is an indirect inhibitor that modulates oxidative stress pathways. It reduces oxidative stress, which can influence the neuronal response to odorants mediated by Olfr725. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is an indirect inhibitor that affects calcium signaling in neurons, modulating intracellular calcium levels and indirectly influencing Olfr725's function in transducing odorant signals by altering calcium-dependent processes in olfactory neurons. | ||||||
Propranolol | 525-66-6 | sc-507425 | 100 mg | $180.00 | ||
Propranolol is an indirect inhibitor that acts on adrenergic receptors, potentially influencing the sympathetic nervous system's impact on olfactory perception and Olfr725's responses to odorants. | ||||||