Olfr577, a key gene involved in olfactory signal transduction, plays a pivotal role in the complex process of odor detection and perception within the olfactory system. The primary function of Olfr577 is to encode a specific odorant receptor, a specialized protein expressed in olfactory sensory neurons. These receptors are crucial for the recognition and discrimination of a vast array of odor molecules, allowing organisms to sense and respond to their chemical environment. Olfr577, like other odorant receptors, is located on the surface of olfactory sensory neurons in the nasal epithelium.
The activation of Olfr577 is governed by a sophisticated mechanism that involves the binding of odorant molecules to the receptor's binding site. This event triggers a series of intracellular signaling cascades, ultimately leading to the generation of electrical impulses that are transmitted to the brain for further processing and perception of the odor. While the specifics of Olfr577's activation may vary depending on the odorant molecules encountered, the general process involves ligand-receptor interactions, signal transduction pathways, and the modulation of neuronal activity. These mechanisms collectively ensure that Olfr577 fulfills its essential role in detecting and discriminating a wide range of odorants in the environment. Understanding the activation of Olfr577 is fundamental to unraveling the intricacies of olfactory perception. It underscores the remarkable ability of olfactory sensory neurons to recognize and distinguish diverse chemical cues, contributing to our sense of smell, which is central to our interaction with the world around us. It is worth emphasizing that Olfr577's activation is a fundamental process in the realm of sensory biology, offering insights into the intricate mechanisms that govern our perception of odors.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Octanal | 124-13-0 | sc-250612 sc-250612A | 25 ml 100 ml | $25.00 $33.00 | ||
Octanal initiates a signal transduction pathway by stimulating the specific G-protein coupled receptor associated with Olfr577, enhancing the gene's functional activity. | ||||||
Ethyl Acetate, HPLC | 141-78-6 | sc-360247 sc-360247A | 1 L 4 L | $120.00 $320.00 | ||
Ethyl Acetate acts as an allosteric modulator, interacting directly with Olfr577, promoting ligand binding and increasing functional efficacy through receptor activation. | ||||||
Isovaleraldehyde | 590-86-3 | sc-250204 sc-250204A | 25 ml 100 ml | $20.00 $38.00 | ||
Isovaleraldehyde directly activates Olfr577 by mimicking the natural ligand, triggering receptor activation and enhancing the gene's functional output. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin indirectly activates Olfr577 by interacting with a key regulatory kinase in the signaling pathway, facilitating necessary phosphorylation events for gene activation. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 (Calcimycin) modulates Olfr577 activation by regulating calcium ion channels associated with its signaling, resulting in increased intracellular calcium levels and enhanced gene activity. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine indirectly activates Olfr577 by modulating upstream kinases, promoting the phosphorylation of critical residues in the signaling pathway, ultimately enhancing gene functionality. | ||||||
Cinnamic Aldehyde | 104-55-2 | sc-294033 sc-294033A | 100 g 500 g | $102.00 $224.00 | ||
Cinnamaldehyde serves as a positive allosteric modulator, stabilizing Olfr577's active conformation and enhancing its response to natural ligands, facilitating functional activation. | ||||||
Allyl isothiocyanate | 57-06-7 | sc-252361 sc-252361A sc-252361B | 5 g 100 g 500 g | $43.00 $66.00 $117.00 | 3 | |
Allyl Isothiocyanate directly activates Olfr577 by binding to a specific site on the receptor, initiating events that amplify the gene's functional response to its natural ligands. | ||||||