Olfr555 Inhibitors
Olfr555, a member of the olfactory receptor family, plays a fundamental role in the intricate process of odor detection. As a G protein-coupled receptor (GPCR) localized on the surface of olfactory sensory neurons within the nasal epithelium, Olfr555 serves as a molecular sensor, responding to a diverse array of odorant molecules. Upon odorant binding, Olfr555 initiates a series of intracellular signaling events, culminating in the generation of neuronal signals transmitted to the brain, contributing to the perception of distinct odors.
Inhibition of Olfr555 involves a sophisticated strategy targeting specific components within signaling pathways intricately linked to its regulation. The inhibitors outlined in the table act either directly or indirectly on Olfr555 through modulation of pathways such as AMPK, PI3K/Akt, NF-κB, JNK, p38 MAPK, MEK, JAK/STAT, TGF-β, and mTOR. These diverse mechanisms of inhibition aim to disrupt the delicate balance that maintains Olfr555 homeostasis, ultimately influencing its expression and functional output. The interplay of these pathways highlights the complexity of Olfr555 regulation and provides valuable insights for further research into chemical interventions for scientific exploration.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR activates AMP-activated protein kinase (AMPK), indirectly inhibiting Olfr555. By activating AMPK, it modulates cellular energy status, impacting pathways critical for Olfr555 regulation. | ||||||
CAL-101 | 870281-82-6 | sc-364453 | 10 mg | $189.00 | 4 | |
CAL-101 is a selective inhibitor of PI3Kδ, influencing the PI3K/Akt pathway. Its indirect effect on Olfr555 is exerted through the disruption of the PI3K/Akt signaling cascade crucial for Olfr555 modulation. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
BAY 11-7082 inhibits NF-κB activation. Its indirect impact on Olfr555 occurs through alterations in cellular responses regulated by the NF-κB pathway, which is involved in Olfr555 modulation. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 inhibits JNK, a component of the JNK signaling pathway. By disrupting this pathway, it indirectly impacts Olfr555, which is responsive to alterations in JNK-mediated cellular responses. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a potent inhibitor of p38 MAPK. Its action on p38 MAPK indirectly influences Olfr555 by altering the cellular environment and signaling cascades that impact Olfr555 activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 inhibits PI3K/Akt signaling, indirectly affecting Olfr555. The PI3K/Akt pathway plays a crucial role in Olfr555 regulation, making this inhibitor an effective indirect modulator. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a selective MEK inhibitor, blocking the MAPK pathway. Its indirect effect on Olfr555 is exerted through the modulation of the MAPK signaling cascade, crucial for Olfr555 regulation. | ||||||
Ruxolitinib | 941678-49-5 | sc-364729 sc-364729A sc-364729A-CW | 5 mg 25 mg 25 mg | $246.00 $490.00 $536.00 | 16 | |
Ruxolitinib inhibits JAK1 and JAK2. By targeting JAK/STAT signaling, it indirectly influences Olfr555, disrupting the pathway linked to Olfr555 regulation. | ||||||
MK-2206 dihydrochloride | 1032350-13-2 | sc-364537 sc-364537A | 5 mg 10 mg | $178.00 $325.00 | 67 | |
MK-2206 is a selective Akt inhibitor. Its indirect impact on Olfr555 occurs through the disruption of the PI3K/Akt pathway, crucial for the regulation of Olfr555. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
SB431542 is a selective inhibitor of TGF-β receptor, influencing TGF-β signaling pathways. Indirectly, it modulates Olfr555, as TGF-β pathways interact with the regulatory mechanisms of Olfr555. | ||||||