Olfr503 Inhibitors
Olfr503, an integral member of the vast olfactory receptor family, is centrally involved in the intricate process of olfactory perception. Positioned within the nasal environment, Olfr503 interacts with odorant molecules, initiating a complex neuronal response that ultimately leads to the perception of specific smells. As part of the G-protein-coupled receptor (GPCR) family arising from single coding-exon genes, Olfr503 shares a 7-transmembrane domain structure with various neurotransmitter and hormone receptors. This structural arrangement underlines its crucial role in recognizing odorant signals and orchestrating G protein-mediated transduction, contributing to the highly nuanced olfactory experience.
The olfactory receptor gene family, characterized by its extensive diversity, holds the distinction of being the largest in the genome. The nomenclature assigned to olfactory receptor genes and proteins is unique to this organism, emphasizing the independence of the olfactory system across different species. In the context of Olfr503's inhibition, a comprehensive understanding of its function is essential. General mechanisms of inhibition involve a diverse array of chemicals acting either directly or indirectly on Olfr503. Direct inhibitors may target specific components of signaling pathways associated with Olfr503, disrupting G-protein signaling or influencing the MAPK pathway. Indirect inhibitors, on the other hand, may modulate cellular processes such as calcium homeostasis, PI3K-Akt signaling, or cAMP-dependent pathways, thereby impacting olfactory signal transduction. The intricate interplay of these chemicals unveils the regulatory networks governing Olfr503, shedding light on the molecular landscape that governs olfactory perception. The disruption of these pathways and processes may alter the neuronal response to odorant signals, ultimately influencing the perception of smells in the olfactory system.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin, a PI3K inhibitor, may indirectly influence Olfr503 by disrupting the PI3K-Akt pathway. This modulation can impact cellular processes associated with olfactory signal transduction, potentially altering the perception of odors. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126, a MEK inhibitor, directly inhibits the MAPK pathway. Its interference with this pathway may influence downstream elements affecting Olfr503, potentially altering G-protein-coupled receptor signaling and impacting olfactory perception. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin, a SERCA inhibitor, may indirectly inhibit Olfr503 by disrupting calcium homeostasis. Changes in intracellular calcium levels could influence G-protein-mediated transduction, altering the neuronal response to odorant signals and impacting olfactory perception. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580, a p38 MAPK inhibitor, directly targets the MAPK pathway. Inhibition of this pathway may affect downstream elements involved in olfactory signal transduction, potentially influencing Olfr503 and altering the perception of odors in the olfactory system. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059, a MEK inhibitor, directly inhibits the MAPK pathway. By disrupting this pathway, it may influence downstream elements affecting Olfr503, potentially altering G-protein-coupled receptor signaling and impacting olfactory perception. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002, a PI3K inhibitor, may indirectly influence Olfr503 by inhibiting the PI3K-Akt pathway. Modulating this pathway could impact cellular processes associated with olfactory signal transduction, potentially affecting the perception of odors. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $178.00 | 25 | |
KN-93, a CaMKII inhibitor, may indirectly affect Olfr503 by modulating calcium/calmodulin-dependent signaling pathways. Disruption of these pathways could impact G-protein-coupled receptor function, potentially altering the neuronal response to odorant signals in the olfactory system. | ||||||
Gallein | 2103-64-2 | sc-202631 | 50 mg | $83.00 | 20 | |
Gallein, a Gβγ inhibitor, directly inhibits Olfr503 by disrupting G-protein signaling. Its interference with G-protein-mediated transduction could impact the neuronal response involved in olfactory signal transduction, affecting the perception of smell. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Verapamil, a calcium channel blocker, could indirectly impact Olfr503 by modulating intracellular calcium levels. Changes in calcium signaling may affect G-protein-mediated transduction and alter the neuronal response to odorant molecules, impacting olfactory perception. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
GF109203X, a PKC inhibitor, may indirectly influence Olfr503 by modulating PKC-mediated signaling pathways. Disruption of these pathways could impact G-protein-coupled receptor function, potentially altering the neuronal response to odorant signals in the olfactory system. | ||||||