Olfr502 Inhibitors
Olfr502, a member of the extensive olfactory receptor family, plays a pivotal role in the intricate process of olfactory perception. As an olfactory receptor protein, Olfr502 operates within the nasal environment, where it interacts with odorant molecules, initiating a neuronal response that culminates in the perception of specific smells. This class of proteins belongs to the G-protein-coupled receptor (GPCR) family, emerging from single coding-exon genes. Structurally, olfactory receptors like Olfr502 share a 7-transmembrane domain architecture with neurotransmitter and hormone receptors, facilitating their responsibility for the recognition and G protein-mediated transduction of odorant signals.
The olfactory receptor gene family, of which Olfr502 is a part, stands as the largest in the genome, reflecting the diversity and complexity of olfactory signaling. The nomenclature assigned to olfactory receptor genes and proteins is unique to this organism, independent of other species. In the context of Olfr502's inhibition, a comprehensive understanding of its function is essential. The general mechanisms of inhibition involve a diverse array of chemicals acting either directly or indirectly on Olfr502. Direct inhibitors may target specific components of signaling pathways associated with Olfr502, disrupting G-protein signaling or influencing the MAPK pathway. Indirect inhibitors, on the other hand, may modulate cellular processes such as calcium homeostasis, PI3K-Akt signaling, or cAMP-dependent pathways, thereby impacting olfactory signal transduction. The intricate interplay of these chemicals unveils the regulatory networks governing Olfr502, shedding light on the molecular landscape that governs olfactory perception. The disruption of these pathways and processes may alter the neuronal response to odorant signals, ultimately influencing the perception of smells in the olfactory system.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Gallein | 2103-64-2 | sc-202631 | 50 mg | $83.00 | 20 | |
Gallein, a Gβγ inhibitor, directly inhibits Olfr502 by disrupting G-protein signaling. Its interference with G-protein-mediated transduction could impact the neuronal response involved in olfactory signal transduction, affecting the perception of smell. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059, a MEK inhibitor, directly inhibits the MAPK pathway. By disrupting this pathway, it may influence downstream elements affecting Olfr502, potentially altering G-protein-coupled receptor signaling and impacting olfactory perception. | ||||||
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $442.00 | 3 | |
PTX (Pertussis toxin) inhibits G-protein signaling. Olfr502, being a GPCR, may be indirectly affected, as pertussis toxin disrupts G-protein-mediated transduction. This interference could alter the neuronal response to odorant signals in the olfactory system. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002, a PI3K inhibitor, may indirectly influence Olfr502 by inhibiting the PI3K-Akt pathway. Modulating this pathway could impact cellular processes associated with olfactory signal transduction, potentially affecting the perception of odors. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Verapamil, a calcium channel blocker, could indirectly impact Olfr502 by modulating intracellular calcium levels. Changes in calcium signaling may affect G-protein-mediated transduction and alter the neuronal response to odorant molecules, impacting olfactory perception. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580, a p38 MAPK inhibitor, directly targets the MAPK pathway. Inhibition of this pathway may affect downstream elements involved in olfactory signal transduction, potentially influencing Olfr502 and altering the perception of odors in the olfactory system. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin, a PI3K inhibitor, could indirectly influence Olfr502 by disrupting the PI3K-Akt pathway. Modulating this pathway may impact cellular processes associated with olfactory signal transduction, potentially affecting the perception of odors. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin, a SERCA inhibitor, may indirectly inhibit Olfr502 by disrupting calcium homeostasis. Changes in intracellular calcium levels could influence G-protein-mediated transduction, altering the neuronal response to odorant signals and impacting olfactory perception. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $178.00 | 25 | |
KN-93, a CaMKII inhibitor, may indirectly affect Olfr502 by modulating calcium/calmodulin-dependent signaling pathways. Disruption of these pathways could impact G-protein-coupled receptor function, potentially altering the neuronal response to odorant signals in the olfactory system. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
GF109203X, a PKC inhibitor, may indirectly influence Olfr502 by modulating PKC-mediated signaling pathways. Disruption of these pathways could impact G-protein-coupled receptor function, potentially altering the neuronal response to odorant signals in the olfactory system. | ||||||