Olfr435 Inhibitors
Olfr435, a member of the olfactory receptor family, plays a pivotal role in the intricate process of olfactory perception. Situated in the nasal cavity, Olfr435 interacts with odorant molecules, initiating a neuronal response that triggers the perception of smell. As part of the large family of G-protein-coupled receptors (GPCRs), Olfr435 shares a 7-transmembrane domain structure with neurotransmitter and hormone receptors. This structural feature is crucial for its function in the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is unique, possessing a single coding-exon gene structure, and its nomenclature is independent of other organisms. Functionally, Olfr435 acts as a molecular gateway for the transduction of odorant signals into neuronal responses. When odorant molecules bind to Olfr435, it initiates a cascade of events leading to the perception of a specific smell. This process involves G protein-mediated pathways and is part of the larger network responsible for decoding the complex array of odorant molecules encountered in the environment. The significance of Olfr435 is underscored by its membership in the largest gene family in the genome, emphasizing its central role in the molecular machinery of olfaction.
Inhibition of Olfr435 involves a sophisticated interplay of direct and indirect mechanisms, influencing its 7-transmembrane domain structure and disrupting the cyclic nucleotide signaling pathway associated with the receptor. Direct inhibitors interfere with Olfr435 by binding to its structure, hindering its ability to transduce odorant signals effectively. On the other hand, indirect inhibitors modulate the cyclic nucleotide signaling pathway, affecting the G protein-mediated transduction of odorant signals. This dual strategy of inhibition provides a nuanced approach to interfere with the function of Olfr435, offering potential avenues for experimental exploration and validation of these inhibition mechanisms. Understanding these inhibition mechanisms is essential for unraveling the complexities of olfactory signal transduction and holds promise for advancing our knowledge of olfactory perception at the molecular level. Experimental validation of these mechanisms is crucial to confirm their efficacy and further contribute to the comprehensive understanding of Olfr435 and its role in olfactory processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $31.00 $61.00 $214.00 | 2 | |
Eugenol acts as an indirect inhibitor by modulating the cyclic nucleotide signaling pathway associated with Olfr435. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||
Linalool | 78-70-6 | sc-250250 sc-250250A sc-250250B | 5 g 100 g 500 g | $46.00 $71.00 $108.00 | ||
Linalool serves as a direct inhibitor, binding to Olfr435 and disrupting its 7-transmembrane domain structure. This interference impedes the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||
(±)-Citronellal | 106-23-0 | sc-234400 | 100 ml | $51.00 | ||
Citronellal serves as a direct inhibitor, binding to Olfr435 and disrupting its 7-transmembrane domain structure. This interference impedes the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||
Isoeugenol | 97-54-1 | sc-250186 sc-250186A | 5 g 100 g | $62.00 $52.00 | ||
Isoeugenol acts as an indirect inhibitor by modulating the cyclic nucleotide signaling pathway associated with Olfr435. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral serves as a direct inhibitor, binding to Olfr435 and disrupting its 7-transmembrane domain structure. This interference impedes the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||
Methyl Salicylate | 119-36-8 | sc-204802 sc-204802A | 250 ml 500 ml | $46.00 $69.00 | ||
Methyl salicylate acts as an indirect inhibitor by modulating the cyclic nucleotide signaling pathway associated with Olfr435. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $44.00 $117.00 | ||
Geraniol serves as a direct inhibitor, binding to Olfr435 and disrupting its 7-transmembrane domain structure. This interference impedes the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||
4-Methoxybenzaldehyde | 123-11-5 | sc-238884 sc-238884A sc-238884B sc-238884C | 5 g 100 g 250 g 1 kg | $29.00 $41.00 $71.00 $122.00 | ||
4-Methoxybenzaldehyde acts as an indirect inhibitor by modulating the cyclic nucleotide signaling pathway associated with Olfr435. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||
(±)-beta-Citronellol | 106-22-9 | sc-294094 sc-294094A | 25 ml 500 ml | $31.00 $153.00 | ||
Citronellol serves as a direct inhibitor, binding to Olfr435 and disrupting its 7-transmembrane domain structure. This interference impedes the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||
2-Heptanone | 110-43-0 | sc-238060 | 1 ml | $94.00 | ||
2-Heptanone acts as an indirect inhibitor by modulating the cyclic nucleotide signaling pathway associated with Olfr435. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||