Olfr420 Inhibitors
The Olfr420 olfactory receptor, a prominent member of the G-protein-coupled receptor (GPCR) family, plays a pivotal role in initiating neuronal responses crucial for perceiving smells. With its 7-transmembrane domain structure, Olfr420 is responsible for the recognition and G protein-mediated transduction of odorant signals, contributing significantly to the intricate landscape of olfactory perception.
The inhibition of Olfr420 involves a sophisticated interplay of direct and indirect mechanisms. Direct inhibitors, such as camphor, eugenol, menthol, isoeugenol, vanillin, and geraniol, act by binding to Olfr420 and disrupting its 7-transmembrane domain structure. This interference impedes the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. On the other hand, indirect inhibitors, including thymol, citral, limonene, linalool, and carvacrol, modulate the cyclic nucleotide signaling pathway associated with Olfr420. Their influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. This diverse array of inhibitors offers a comprehensive approach to disrupting Olfr420's role in odor recognition, providing avenues for experimental exploration and validation of these inhibition mechanisms. Experimental validation is crucial to confirming the efficacy of these inhibitors in practice and further unraveling the intricacies of olfactory signal transduction mediated by Olfr420.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Thymol | 89-83-8 | sc-215984 sc-215984A | 100 g 500 g | $97.00 $193.00 | 3 | |
Thymol acts as an indirect inhibitor by modulating the cyclic nucleotide signaling pathway associated with Olfr420. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $32.00 $62.00 $218.00 | 2 | |
Eugenol functions as a direct inhibitor, binding to Olfr420 and disrupting its 7-transmembrane domain structure. This interference impedes the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral acts as an indirect inhibitor by modulating the cyclic nucleotide signaling pathway associated with Olfr420. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||
(−)-Menthol | 2216-51-5 | sc-202705 sc-202705A | 1 g 50 g | $20.00 $41.00 | 2 | |
Menthol serves as a direct inhibitor, binding to Olfr420 and disrupting its 7-transmembrane domain structure. This interference impedes the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||
D-Limonene | 5989-27-5 | sc-205283 sc-205283A | 100 ml 500 ml | $84.00 $129.00 | 3 | |
Limonene acts as an indirect inhibitor by modulating the cyclic nucleotide signaling pathway associated with Olfr420. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||
Isoeugenol | 97-54-1 | sc-250186 sc-250186A | 5 g 100 g | $63.00 $53.00 | ||
Isoeugenol functions as a direct inhibitor, binding to Olfr420 and disrupting its 7-transmembrane domain structure. This interference impedes the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||
Linalool | 78-70-6 | sc-250250 sc-250250A sc-250250B | 5 g 100 g 500 g | $47.00 $72.00 $110.00 | ||
Linalool acts as an indirect inhibitor by modulating the cyclic nucleotide signaling pathway associated with Olfr420. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||
Vanillin | 121-33-5 | sc-251423 sc-251423A | 100 g 500 g | $44.00 $124.00 | 1 | |
Vanillin serves as a direct inhibitor, binding to Olfr420 and disrupting its 7-transmembrane domain structure. This interference impedes the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $45.00 $119.00 | ||
Geraniol functions as a direct inhibitor, binding to Olfr420 and disrupting its 7-transmembrane domain structure. This interference impedes the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||
(±)-Citronellal | 106-23-0 | sc-234400 | 100 ml | $51.00 | ||
Citronellal acts as an indirect inhibitor by modulating the cyclic nucleotide signaling pathway associated with Olfr420. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||