Olfr412 Inhibitors
The Olfr412 olfactory receptor, a key member of the G-protein-coupled receptor (GPCR) family, plays a pivotal role in initiating neuronal responses essential for the perception of smell. Interacting with odorant molecules in the nose, Olfr412, characterized by a 7-transmembrane domain structure shared with neurotransmitter and hormone receptors, facilitates G protein-mediated transduction of odorant signals. As part of the extensive olfactory receptor gene family, Olfr412 significantly contributes to the complexities of olfactory recognition, highlighting its significance in the sensory experience.
Inhibition of Olfr412 involves a nuanced orchestration of direct and indirect mechanisms. Direct inhibitors, exemplified by camphor, thujone, vanillin, citronellal, anethole, and 2,5-dimethylpyrazine, act by binding to Olfr412 and disrupting its 7-transmembrane domain structure. This interference hampers the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. On the other hand, indirect inhibitors, such as ethyl acetate, isoamyl butyrate, naphthalene, isoamyl acetoacetate, and butyric acid, modulate the cyclic nucleotide signaling pathway associated with Olfr412. Their influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. The diverse array of inhibitors offers a comprehensive approach to disrupting Olfr412's role in odor recognition, providing avenues for experimental exploration and validation of these inhibition mechanisms. Experimental validation is essential to confirm the efficacy of these inhibitors in practice and further unravel the intricacies of olfactory signal transduction mediated by Olfr412.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ethyl Acetate, HPLC | 141-78-6 | sc-360247 sc-360247A | 1 L 4 L | $120.00 $320.00 | ||
Ethyl acetate functions as an indirect inhibitor by modulating the cyclic nucleotide signaling pathway associated with Olfr412. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||
Isopentyl butyrate | 106-27-4 | sc-269267 | 100 g | $67.00 | ||
Isoamyl butyrate acts as an indirect inhibitor by modulating the cyclic nucleotide signaling pathway associated with Olfr412. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||
Vanillin | 121-33-5 | sc-251423 sc-251423A | 100 g 500 g | $43.00 $122.00 | 1 | |
Vanillin serves as a direct inhibitor by binding to Olfr412, disrupting the 7-transmembrane domain structure. This interference hampers the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||
Naphthalene | 91-20-3 | sc-215533 sc-215533A | 250 mg 5 g | $20.00 $36.00 | ||
Naphthalene acts as an indirect inhibitor by modulating the cyclic nucleotide signaling pathway associated with Olfr412. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||
(±)-Citronellal | 106-23-0 | sc-234400 | 100 ml | $51.00 | ||
Citronellal functions as a direct inhibitor by binding to Olfr412, disrupting the 7-transmembrane domain structure. This interference impedes the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||
trans-Anethole | 4180-23-8 | sc-253727 | 1 ml | $27.00 | 1 | |
Anethole serves as a direct inhibitor by binding to Olfr412, disrupting the 7-transmembrane domain structure. This interference hampers the receptor's ability to transduce odorant signals through G protein-mediated pathways, leading to the inhibition of olfactory perception. | ||||||
Acetic acid | 64-19-7 | sc-214462 sc-214462A | 500 ml 2.5 L | $62.00 $104.00 | 5 | |
Acetic acid acts as an indirect inhibitor by modulating the cyclic nucleotide signaling pathway associated with Olfr412. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||
Butyric acid | 107-92-6 | sc-214640 sc-214640A | 1 kg 10 kg | $63.00 $174.00 | ||
Butyric acid serves as an indirect inhibitor by modulating the cyclic nucleotide signaling pathway associated with Olfr412. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||