Olfr410 Inhibitors
The Olfr410 olfactory receptor, a prominent member of the G-protein-coupled receptor (GPCR) family, orchestrates the initiation of a neuronal response crucial for the perception of smell by interacting with odorant molecules in the nose. The receptor, characterized by a 7-transmembrane domain structure shared with neurotransmitter and hormone receptors, plays a pivotal role in the G protein-mediated transduction of odorant signals. As part of the expansive olfactory receptor gene family, Olfr410 contributes significantly to the intricacies of olfactory recognition, underscoring its importance in the sensory experience.
The inhibition of Olfr410 involves a strategic interplay of direct and indirect mechanisms. Direct inhibitors, including benzyl acetate, isoamyl butyrate, ethyl acetate, octanoic acid, butanoic acid, and pentanoic acid, disrupt the receptor's function by binding to it and interfering with the 7-transmembrane domain structure. This interference hampers the receptor's ability to effectively transduce odorant signals through G protein-mediated pathways, leading to the inhibition of olfactory perception. On the other hand, indirect inhibitors, such as geraniol, linalool, 2-heptanone, anisole, 2,3-butanedione, and benzaldehyde, target associated signaling pathways, including cAMP. Their modulation of these pathways leads to altered G protein-mediated transduction of odorant signals, providing an additional layer of inhibition for Olfr410. The diverse array of inhibitors presents a comprehensive approach to disrupting Olfr410's role in odor recognition, offering avenues for experimental exploration and validation of these inhibition mechanisms. Experimental validation is essential to confirm the efficacy of these inhibitors in practice and further unravel the intricacies of olfactory signal transduction mediated by Olfr410.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Benzyl acetate | 140-11-4 | sc-252427 | 100 g | $30.00 | 1 | |
Benzyl acetate acts as a direct inhibitor by binding to Olfr410, disrupting the 7-transmembrane domain structure. This interference impedes the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $45.00 $119.00 | ||
Geraniol serves as an indirect inhibitor by modulating the cAMP signaling pathway associated with Olfr410. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||
Isopentyl butyrate | 106-27-4 | sc-269267 | 100 g | $67.00 | ||
Isopentyl butyrate functions as a direct inhibitor by binding to Olfr410, disrupting the 7-transmembrane domain structure. This interference hampers the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||
Linalool | 78-70-6 | sc-250250 sc-250250A sc-250250B | 5 g 100 g 500 g | $47.00 $72.00 $110.00 | ||
Linalool acts as an indirect inhibitor by modulating the cAMP signaling pathway associated with Olfr410. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||
Ethyl Acetate, HPLC | 141-78-6 | sc-360247 sc-360247A | 1 L 4 L | $122.00 $326.00 | ||
Ethyl acetate serves as a direct inhibitor by binding to Olfr410, disrupting the 7-transmembrane domain structure. This interference impedes the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||
2-Heptanone | 110-43-0 | sc-238060 | 1 ml | $94.00 | ||
2-Heptanone acts as an indirect inhibitor by modulating the cAMP signaling pathway associated with Olfr410. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||
Anisole | 100-66-3 | sc-233877 sc-233877A | 500 ml 2.5 L | $65.00 $204.00 | ||
Anisole serves as an indirect inhibitor by modulating the cAMP signaling pathway associated with Olfr410. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||
Butyric acid | 107-92-6 | sc-214640 sc-214640A | 1 kg 10 kg | $64.00 $177.00 | ||
Butyric acid acts as a direct inhibitor by binding to Olfr410, disrupting the 7-transmembrane domain structure. This interference impedes the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||