Olfr380 Inhibitors

Or1e21, a key member of the olfactory receptor family 1 subfamily E in Mus musculus (house mouse), is integral to the complex process of olfactory perception. Functioning as a G-protein-coupled receptor (GPCR), Or1e21 facilitates the interaction between odorant molecules and the nasal environment, initiating neuronal responses that trigger the perception of smells. This receptor shares a structural framework characterized by a 7-transmembrane domain with other neurotransmitter and hormone receptors, signifying its involvement in the recognition and G protein-mediated transduction of odorant signals. As a part of the extensive olfactory receptor gene family, which stands as the largest in the genome, Or1e21 holds a central role in the sophisticated molecular machinery that underlies the sense of smell in house mice.

The general mechanisms of inhibiting Or1e21 reveal a complex interplay of diverse inhibitors targeting various cellular pathways crucial for GPCR-mediated transduction of odorant signals. These inhibitors disrupt downstream signaling pathways through direct or indirect means, hindering the normal functioning of Or1e21. Examples include antagonizing neurokinin receptors, blocking ryanodine receptors, inhibiting TRPV1 receptors, and targeting angiotensin receptors, among others. These intricate actions impede the receptor's ability to initiate neuronal responses in the presence of odorant molecules, illustrating the multifaceted nature of GPCR-mediated olfactory transduction. The diverse mechanisms of inhibition underscore the intricate regulatory network governing Or1e21 and provide valuable insights into the complex interplay between receptor function and the regulatory pathways within cellular environments. This comprehensive understanding enhances our knowledge of the molecular basis of olfactory perception in house mice, shedding light on the intricate orchestration of events involved in odorant signal transduction.