Olfr367 Inhibitors
Or7c74, a member of the olfactory receptor family 7 subfamily C, orchestrates a fundamental role in the intricate process of olfaction, serving as a molecular sentinel for detecting and transducing odorant signals. As a G-protein-coupled receptor (GPCR), Or7c74 arises from a single coding-exon gene, sharing a structural foundation of a 7-transmembrane domain with neurotransmitter and hormone receptors. Positioned in the nasal environment, Or7c74 engages in a highly specialized interaction with odorant molecules, initiating a neuronal response that triggers the perception of a diverse array of smells. Within the context of the olfactory receptor gene family, Or7c74 contributes to the intricate landscape of the largest gene family in the genome dedicated to olfactory reception.
The inhibition of Or7c74 unfolds through a sophisticated interplay of direct and indirect mechanisms, shedding light on potential strategies to modulate its activity. Direct inhibitors exert their influence by binding to Or7c74, disrupting its interaction with odorant molecules and, consequently, hindering the normal G protein-mediated transduction of odorant signals. This direct interference leads to the inhibition of Or7c74, resulting in compromised perception of smell. In contrast, indirect inhibitors operate through the modulation of specific signaling pathways intricately associated with Or7c74 function. These pathways include NF-κB, PI3K/Akt, MAPK, cAMP, and calcium signaling, among others. The impact of these compounds on downstream components of these signaling cascades results in the indirect inhibition of Or7c74 expression and function. The versatile nature of these mechanisms underscores potential avenues for the regulation of olfactory receptor activity, providing a comprehensive understanding of the complex regulatory network governing Or7c74 and its crucial role in olfaction. In conclusion, the exploration of Or7c74's function and inhibition unveils the intricate nature of olfactory receptor-mediated perception, offering a foundation for further experimental investigations in the realm of olfactory sensation and receptor modulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(±)-Menthol | 89-78-1 | sc-250299 sc-250299A | 100 g 250 g | $38.00 $67.00 | ||
Menthol serves as a direct inhibitor by binding to Or7c74, disrupting its interaction with odorant molecules. This direct interference hampers the normal G protein-mediated transduction of odorant signals, leading to the inhibition of Or7c74 and subsequent hindrance in the perception of smell. | ||||||
(±)-Citronellal | 106-23-0 | sc-234400 | 100 ml | $51.00 | ||
Citronellal acts as an indirect inhibitor by modulating the NF-κB signaling pathway. It influences the downstream components of the NF-κB pathway, indirectly inhibiting Or7c74 expression and function. The altered NF-κB signaling cascades disrupt the normal transduction of odorant signals, leading to indirect inhibition. | ||||||
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $105.00 $221.00 | ||
Isopentyl acetate serves as a direct inhibitor by binding to Or7c74, interfering with its interaction with odorant molecules. This direct disruption of the neuronal response inhibits the perception of smell mediated by Or7c74, hindering the initiation of the olfactory signaling cascade. | ||||||
Thymol | 89-83-8 | sc-215984 sc-215984A | 100 g 500 g | $97.00 $193.00 | 3 | |
Thymol acts as an indirect inhibitor by influencing the PI3K/Akt signaling pathway. It modulates the downstream components of this pathway, indirectly inhibiting Or7c74 expression and function. The altered PI3K/Akt signaling cascades disrupt the normal transduction of odorant signals, leading to indirect inhibition. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $31.00 $61.00 $214.00 | 2 | |
Eugenol acts as a direct inhibitor by binding to Or7c74, disrupting its interaction with odorant molecules. This direct interference hampers the normal G protein-mediated transduction of odorant signals, leading to the inhibition of Or7c74 and subsequent hindrance in the perception of smell. | ||||||
D-Limonene | 5989-27-5 | sc-205283 sc-205283A | 100 ml 500 ml | $82.00 $126.00 | 3 | |
D-Limonene acts as an indirect inhibitor by modulating the MAPK signaling pathway. It influences the downstream components of the MAPK pathway, indirectly inhibiting Or7c74 expression and function. The altered MAPK signaling cascades disrupt the normal transduction of odorant signals, leading to indirect inhibition. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $44.00 $117.00 | ||
Geraniol acts as an indirect inhibitor by modulating the cAMP signaling pathway. It influences the downstream components of the cAMP pathway, indirectly inhibiting Or7c74 expression and function. The altered cAMP signaling cascades disrupt the normal transduction of odorant signals, leading to indirect inhibition. | ||||||
2-Phenylethanol | 60-12-8 | sc-238198 | 250 ml | $68.00 | ||
2-Phenylethanol serves as a direct inhibitor by binding to Or7c74, disrupting its interaction with odorant molecules. This direct interference hampers the normal G protein-mediated transduction of odorant signals, leading to the inhibition of Or7c74 and subsequent hindrance in the perception of smell. | ||||||
Allyl isothiocyanate | 57-06-7 | sc-252361 sc-252361A sc-252361B | 5 g 100 g 500 g | $43.00 $66.00 $117.00 | 3 | |
Allyl Isothiocyanate acts as an indirect inhibitor by modulating the cyclic nucleotide signaling pathway. It influences the downstream components of the cyclic nucleotide pathway, indirectly inhibiting Or7c74 expression and function. The altered cyclic nucleotide signaling cascades disrupt the normal transduction of odorant signals, leading to indirect inhibition. | ||||||