Olfr366 Inhibitors
Or1af1, a distinguished member of the olfactory receptor family, orchestrates a critical role in the intricate process of olfaction, contributing significantly to the perception of smell. As a G-protein-coupled receptor (GPCR) arising from a single coding-exon gene, Or1af1 shares the characteristic 7-transmembrane domain structure with neurotransmitter and hormone receptors. This receptor is integral to the recognition and G protein-mediated transduction of odorant signals, representing a key player in the largest gene family in the genome dedicated to olfactory reception.
The inhibition of Or1af1 is intricately regulated by a repertoire of direct and indirect mechanisms, each shedding light on potential strategies for controlling its activity. Direct inhibitors exert their influence by binding to Or1af1, disrupting its interaction with odorant molecules and, subsequently, hindering the normal G protein-mediated transduction of odorant signals. These direct interferences lead to the inhibition of Or1af1, resulting in a compromised perception of smell. Conversely, indirect inhibitors operate by modulating specific signaling pathways intricately associated with Or1af1 function. These pathways include NF-κB, cAMP, PI3K/Akt, MAPK, cyclic nucleotide, and calcium signaling, among others. The impact of these compounds on downstream components of these signaling cascades results in the indirect inhibition of Or1af1 expression and function. The versatility of these mechanisms highlights potential avenues for the regulation of olfactory receptor activity, providing a comprehensive understanding of the complex regulatory network governing Or1af1 and its role in olfaction. In conclusion, the exploration of Or1af1's function and inhibition unveils the intricate nature of olfactory receptor-mediated perception, offering a foundation for further experimental investigations in the realm of olfactory sensation and receptor modulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral serves as an indirect inhibitor by modulating the NF-κB signaling pathway. It influences the downstream components of the NF-κB pathway, indirectly inhibiting Or1af1 expression and function. The altered NF-κB signaling cascades disrupt the normal transduction of odorant signals, leading to indirect inhibition. | ||||||
Thymol | 89-83-8 | sc-215984 sc-215984A | 100 g 500 g | $97.00 $193.00 | 3 | |
Thymol serves as an indirect inhibitor by influencing the PI3K/Akt signaling pathway. It modulates the downstream components of this pathway, indirectly inhibiting Or1af1 expression and function. The altered PI3K/Akt signaling cascades disrupt the normal transduction of odorant signals, leading to indirect inhibition. | ||||||
Linalool | 78-70-6 | sc-250250 sc-250250A sc-250250B | 5 g 100 g 500 g | $47.00 $72.00 $110.00 | ||
Linalool acts as a direct inhibitor by binding to Or1af1, disrupting its interaction with odorant molecules. This direct interference hampers the normal G protein-mediated transduction of odorant signals, leading to the inhibition of Or1af1 and subsequent hindrance in the perception of smell. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $45.00 $119.00 | ||
Geraniol acts as an indirect inhibitor by modulating the cAMP signaling pathway. It influences the downstream components of the cAMP pathway, indirectly inhibiting Or1af1 expression and function. The altered cAMP signaling cascades disrupt the normal transduction of odorant signals, leading to indirect inhibition. | ||||||
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $107.00 $225.00 | ||
Isopentyl acetate serves as a direct inhibitor by binding to Or1af1, interfering with its interaction with odorant molecules. This direct disruption of the neuronal response inhibits the perception of smell mediated by Or1af1, hindering the initiation of the olfactory signaling cascade. | ||||||
D-Limonene | 5989-27-5 | sc-205283 sc-205283A | 100 ml 500 ml | $84.00 $129.00 | 3 | |
D-Limonene acts as an indirect inhibitor by modulating the MAPK signaling pathway. It influences the downstream components of the MAPK pathway, indirectly inhibiting Or1af1 expression and function. The altered MAPK signaling cascades disrupt the normal transduction of odorant signals, leading to indirect inhibition. | ||||||
Allyl isothiocyanate | 57-06-7 | sc-252361 sc-252361A sc-252361B | 5 g 100 g 500 g | $44.00 $67.00 $119.00 | 3 | |
Allyl Isothiocyanate acts as a direct inhibitor by binding to Or1af1, disrupting its interaction with odorant molecules. This direct interference hampers the normal G protein-mediated transduction of odorant signals, leading to the inhibition of Or1af1 and subsequent hindrance in the perception of smell. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $32.00 $62.00 $218.00 | 2 | |
Eugenol acts as an indirect inhibitor by modulating the cyclic nucleotide signaling pathway. It influences the downstream components of the cyclic nucleotide pathway, indirectly inhibiting Or1af1 expression and function. The altered cyclic nucleotide signaling cascades disrupt the normal transduction of odorant signals, leading to indirect inhibition. | ||||||
Acetophenone | 98-86-2 | sc-239189 | 5 g | $20.00 | ||
Acetophenone serves as a direct inhibitor by binding to Or1af1, interfering with its interaction with odorant molecules. This direct disruption of the neuronal response inhibits the perception of smell mediated by Or1af1, hindering the initiation of the olfactory signaling cascade. | ||||||