Obox5 Activators
Obox5 activators encompass a diverse group of chemical compounds that influence various signaling pathways and transcriptional regulation mechanisms. These activators, while not directly interacting with Obox5, modulate cellular processes that converge on the transcriptional activation of the gene. For instance, compounds like forskolin, dibutyryl-cAMP, and 8-bromo-cAMP elevate intracellular levels of cAMP, a second messenger that activates protein kinase A. Activated PKA can phosphorylate transcription factors that regulate gene expression, thereby potentially influencing Obox5. Similarly, phorbol 12-myristate 13-acetate (PMA) activates protein kinase C, another kinase that can modify the activity of transcriptional regulators.
Other activators, such as retinoic acid and 3,5-diiodo-L-thyronine, engage with nuclear hormone receptors and subsequently alter the transcription of genes by remodeling the chromatin landscape or by modifying the pool of transcriptional co-activators and co-repressors. Lithium chloride and histone deacetylase inhibitors like Trichostatin A alter the phosphorylation status of proteins and the chromatin structure, respectively, thereby influencing the transcriptional activity relevant to Obox5. Autophagy and endosomal acidification, affected by chloroquine, represent additional cellular processes that can have secondary effects on gene regulation. Collectively, these activators utilize different pathways to potentially impact the activation state of Obox5, a transcription factor involved in gene regulation by RNA polymerase II.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is an adenylyl cyclase activator, which increases the levels of cyclic AMP (cAMP) in cells. Elevated cAMP can enhance the activity of protein kinase A (PKA), which in turn can phosphorylate transcription factors that may interact with Obox5, leading to its activation. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is a cell-permeable cAMP analog. By mimicking cAMP, it can activate PKA, potentially influencing transcription factors that modulate Obox5 activity. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid, a metabolite of vitamin A, acts on retinoic acid receptors and can modulate gene expression. It may affect transcriptional regulation pathways involving Obox5. | ||||||
3,5-Diiodo-L-thyronine | 1041-01-6 | sc-216601 sc-216601A sc-216601B sc-216601C sc-216601D | 1 g 5 g 10 g 25 g 100 g | $265.00 $551.00 $920.00 $1380.00 $2621.00 | 2 | |
As an analog of thyroid hormones, 3,5-Diiodo-L-thyronine can influence nuclear thyroid hormone receptors and could indirectly affect transcriptional regulation pathways, possibly impacting Obox5 activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a protein kinase C (PKC) activator. PKC activation can lead to alterations in phosphorylation states of transcription factors, thereby potentially influencing Obox5 activity. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $106.00 $166.00 $289.00 $550.00 $819.00 | 2 | |
This is a cAMP analog that activates PKA, similar to dibutyryl-cAMP, and could indirectly support Obox5 activation through phosphorylation of transcriptional regulators. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that can increase intracellular cAMP levels, which may lead to PKA activation and subsequent modulation of transcription factors relevant to Obox5 activation. | ||||||
Bimatoprost | 155206-00-1 | sc-205224 sc-205224A | 1 mg 5 mg | $118.00 $455.00 | 1 | |
Bimatoprost, a prostaglandin analog, can modulate prostaglandin receptors and downstream signaling, potentially influencing transcription factors that regulate Obox5. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride can inhibit glycogen synthase kinase-3 (GSK-3), leading to modulation of signaling pathways that could indirectly influence Obox5 activity via transcriptional regulation. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
These inhibitors can change the chromatin structure, leading to altered gene expression patterns that might affect Obox5 activation. | ||||||