Obox1 Activators
Oocyte specific homeobox 1 (Obox1) Activators are a group of chemicals that can influence DNA-binding transcription factor activity, often through indirect means, such as modifying the cellular signaling pathways. These activators can increase the levels of secondary messengers, such as cAMP or intracellular calcium, or directly modulate the activity of key kinases and phosphatases that are upstream of transcriptional regulation machinery involving Obox1. Some activators, like Forskolin and Isoproterenol, function by increasing intracellular cAMP levels, which can enhance PKA activity and potentially lead to the phosphorylation of proteins that interact with or regulate Obox1. Others, such as A23187 and Ionomycin, increase intracellular calcium, which can trigger signaling cascades involving calcium-dependent proteins, potentially influencing transcription factors or co-regulators that interact with Obox1. These dynamic shifts in the cellular environment foster a context in which Obox1 activity might be modulated. For instance, calcium ionophores like A23187 and Ionomycin raise calcium levels, indirectly affecting transcriptional regulation that Obox1 may be part of.
Pharmacologically, agents such as PMA and Chlorpromazine offer insights into the modulation of kinase and phosphatase activities, respectively. PMA activates PKC, which is known for its role in the phosphorylation of various proteins that could interact with Obox1, altering its transcription factor activity. Conversely, Chlorpromazine, by inhibiting calmodulin, can interfere with calcium signaling, which may indirectly impact Obox1's role in gene regulation.Specifically, these chemicals might activate or modulate various signaling pathways that converge on the transcriptional machinery to which Obox1 is a contributor. This would result in an indirect promotion of Obox1's ability to engage with its cis-regulatory sequences, thereby influencing gene expression. The exact molecular mechanisms by which these activators influence Obox1, however, would remain an area for future cellular and molecular research.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is a labdane diterpene produced by the Indian Coleus plant. It increases levels of cyclic AMP (cAMP) in cells by activating the enzyme adenylate cyclase, which converts ATP to cAMP. Elevated cAMP levels can enhance the activity of protein kinase A (PKA), which may phosphorylate transcription factors or other proteins that interact with Obox1, leading to its activation. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $106.00 $166.00 $289.00 $550.00 $819.00 | 2 | |
8-Bromo-cAMP is a cell-permeable cAMP analogue. It activates PKA, mimicking the action of cAMP, and can phosphorylate target proteins. Consequently, it may indirectly activate Obox1 by promoting the phosphorylation of transcription factors or coactivators involved in Obox1-mediated transcription. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a synthetic catecholamine and non-selective beta-adrenergic agonist. By stimulating beta-adrenergic receptors, it leads to the activation of adenylate cyclase and a subsequent increase in cAMP. This increase in cAMP can enhance PKA activity, potentially influencing the transcriptional activity of Obox1. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a diester of phorbol and functions as a protein kinase C (PKC) activator. PKC activation can lead to the phosphorylation and modulation of various downstream proteins that could affect Obox1 activity, including transcription factors that may work in concert with Obox1. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is an ionophore that facilitates the transport of calcium ions across cellular membranes. Elevated intracellular calcium levels can activate various calcium-dependent proteins and pathways, potentially affecting transcription factors or co-activators that modulate Obox1 function. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid, a metabolite of vitamin A, binds to retinoic acid receptors and can regulate gene expression. It may modulate transcription factors or co-regulatory proteins that interact with or modulate the transcriptional activity of Obox1. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $60.00 $108.00 | 21 | |
Chlorpromazine is a phenothiazine antipsychotic that can inhibit calmodulin, which is involved in calcium signaling. By altering calcium signaling, it may indirectly influence the activity of transcription factors or coactivators that work with Obox1 in gene regulation. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $92.00 $277.00 $969.00 | 7 | |
Histamine can bind to its receptors and activate adenylate cyclase, increasing cAMP levels. The elevated cAMP can activate PKA, which might modulate the activity of transcription factors or coactivators that are involved in Obox1-mediated transcription. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I is a specific inhibitor of PKC. By inhibiting PKC, it could alter the phosphorylation status of proteins that interact with Obox1, potentially affecting the transcriptional regulation activity of Obox1. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentration. This can activate signaling pathways that involve calcium-dependent proteins, which might lead to modulation of the transcriptional activity of Obox1. | ||||||