NXF7 Activators
NXF7 Activators are a chemical class involving a diverse array of compounds that alter various cellular processes, thereby indirectly affecting the function of the nuclear RNA export factor 7 (NXF7) protein. These compounds are not direct activators of NXF7; rather, they influence the cellular environment in which NXF7 operates. For example, some chemicals in this class inhibit transcription or modify chromatin structure, leading to secondary effects on mRNA processing and export.
Others induce cellular stress responses that may necessitate the increased involvement of NXF7 to maintain efficient mRNA export from the nucleus. The common thread among these activators is their capacity to create a cellular context that necessitates or enhances the functional role of NXF7 in transporting mRNA molecules from the nucleus to the cytoplasm. Such indirect activation mechanisms are critical for understanding how NXF7 activity can be modulated under varying cellular conditions.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Leptomycin B | 87081-35-4 | sc-358688 sc-358688A sc-358688B | 50 µg 500 µg 2.5 mg | $107.00 $416.00 $1248.00 | 35 | |
Leptomycin B is an inhibitor of the CRM1/exportin 1 nuclear export pathway. By inhibiting CRM1, leptomycin B can cause the accumulation of proteins inside the nucleus, which may indirectly increase the demand for NXF7 function. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin is a platinum-based compound that causes DNA damage. In response to DNA damage, cells may alter mRNA export mechanisms, potentially increasing NXF7 activity as the cell compensates for the stress. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D binds to DNA and inhibits transcription. This compound can lead to alterations in RNA processing and export, potentially affecting NXF7 activity as the cell adapts to the decreased transcriptional output. | ||||||
2′-Deoxyadenosine monohydrate | 16373-93-6 | sc-216290 sc-216290A | 250 mg 1 g | $32.00 $47.00 | 2 | |
2'-Deoxyadenosine is a deoxyribonucleoside that can interfere with RNA processing. Disruption in processing may necessitate an alteration in RNA export patterns, indirectly influencing NXF7 activity. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $43.00 $189.00 $316.00 $663.00 | 6 | |
5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) is a transcription inhibitor that prevents RNA polymerase II elongation. This can indirectly affect NXF7 activity by changing the nuclear RNA landscape. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that changes chromatin structure and can influence gene expression. This may indirectly modulate NXF7's role in mRNA export. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
Geldanamycin binds to Hsp90 and inhibits its function. This can lead to a stress response that may impact RNA export processes and potentially the activity of NXF7. | ||||||
Arsenic(III) oxide | 1327-53-3 | sc-210837 sc-210837A | 250 g 1 kg | $89.00 $228.00 | ||
Arsenic trioxide can induce a cellular stress response and affect numerous pathways, including those involved in mRNA processing and export, which may indirectly impact NXF7 activity. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin disrupts calcium homeostasis by blocking the endoplasmic reticulum Ca2+ ATPase. This disruption can lead to a stress response that might affect mRNA export and NXF7 activity. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin inhibits N-linked glycosylation, causing ER stress. Cellular responses to ER stress can include alterations in mRNA export mechanisms where NXF7 may be indirectly impacted. | ||||||