NusA Inhibitors
The chemical class known as NusA inhibitors comprises a meticulously selected group of compounds designed to modulate the activity of NusA through targeted interference with transcriptional and translational processes. Rifampicin, Actinomycin D, Ciprofloxacin, Myxopyronin B, Streptolydigin, GreB, Fidaxomicin, Sorangicin A, Thiolutin, Microcin J25, Alpha-Amanitin, and Thiostrepton each present a unique strategy for influencing NusA activity. These compounds predominantly act by interfering with RNA polymerase, the key enzyme in transcription. Rifampicin, for instance, inhibits bacterial RNA polymerase, leading to indirect modulation of NusA by hindering transcription elongation in bacteria. Actinomycin D, Ciprofloxacin, Myxopyronin B, Streptolydigin, Fidaxomicin, Sorangicin A, Thiolutin, Microcin J25, and Alpha-Amanitin also influence NusA through their specific interactions with RNA polymerase.
Additionally, GreB, a bacterial protein, enhances RNA polymerase backtracking, influencing the transcription process and subsequently modulating NusA. Thiostrepton, on the other hand, is a thiopeptide antibiotic that affects bacterial protein synthesis, indirectly influencing NusA by interfering with the translation process. In conclusion, the NusA inhibitors chemical class serves as a sophisticated toolkit for scientists aiming to investigate NusA function by manipulating transcriptional and translational processes. Each compound within this class offers a specific and nuanced approach, ensuring precise control over the molecular mechanisms that govern NusA activity. This class represents a valuable resource for advancing our understanding of NusA's role in cellular processes.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $95.00 $322.00 $663.00 $1438.00 | 6 | |
Rifampicin, a potent antibiotic, inhibits bacterial RNA polymerase. Through this mechanism, it indirectly influences NusA by hindering transcription elongation in bacteria. The compound's specificity for RNA polymerase ensures precise control over the pathway, subsequently modulating NusA activity. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D is a potent DNA intercalator and transcription inhibitor. By preventing RNA synthesis, it indirectly modulates NusA function. The compound's specific interaction with DNA and RNA polymerase ensures precise control over the pathway, subsequently influencing NusA activity. | ||||||
Ciprofloxacin | 85721-33-1 | sc-217900 | 1 g | $42.00 | 8 | |
Ciprofloxacin, a fluoroquinolone antibiotic, inhibits bacterial DNA gyrase. By interfering with DNA replication, it indirectly modulates NusA function. The compound's specificity for DNA gyrase ensures precise control over the pathway, subsequently influencing NusA activity. | ||||||
Thiolutin | 87-11-6 | sc-200387 sc-200387A | 1 mg 5 mg | $99.00 $398.00 | 1 | |
Thiolutin is an antibiotic that inhibits bacterial RNA polymerase. By interfering with transcription elongation, it indirectly modulates NusA function. The compound's specificity for RNA polymerase ensures precise control over the pathway, subsequently influencing NusA activity. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
Alpha-Amanitin is a cyclic peptide toxin that inhibits eukaryotic RNA polymerase II. By interfering with transcription, it indirectly modulates NusA function. The compound's specificity for RNA polymerase II ensures precise control over the pathway, subsequently influencing NusA activity. | ||||||
Thiostrepton | 1393-48-2 | sc-203412 sc-203412A | 1 g 5 g | $115.00 $415.00 | 10 | |
Thiostrepton is a thiopeptide antibiotic that inhibits bacterial protein synthesis. By affecting translation, it indirectly modulates NusA function. The compound's specificity for the translation process ensures precise control over the pathway, subsequently influencing NusA activity. | ||||||