Nup43 Activators
Nup43 activators encompass a range of chemicals known to modify key cellular processes, which can, in turn, influence the function or status of Nup43 within the nuclear pore complex. Some of these chemicals, such as Forskolin, modify intracellular signaling cascades like the cAMP pathway, which plays fundamental roles in numerous cellular processes, including those that could intersect with NPC function.
Phosphorylation, a primary mechanism by which protein function can be modified, is a recurrent theme among the suggested activators. Chemicals such as Okadaic acid, PMA, and Calyculin A exert their influence through the modulation of protein kinases and phosphatases, thereby affecting the phosphorylation status of nucleoporins, possibly including Nup43. This demonstrates the intricate connection between broader cellular signaling pathways and the specialized function of nuclear transport mediated by the NPC. Similarly, chemicals like U0126, MG132, and the PI3K inhibitors Wortmannin and LY294002 further emphasize the diverse signaling pathways that can potentially interact with NPC components.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Elevates cAMP levels, which can influence numerous cellular processes, including NPC functionality. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
An inhibitor of protein phosphatases, which can affect phosphorylation status of NPC components and may influence Nup43 function. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Activates protein kinase C (PKC), potentially impacting the phosphorylation of nucleoporins like Nup43. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
A proteasome inhibitor; can influence protein turnover and potentially affect Nup43 within the NPC. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Interferes with microtubule polymerization; can affect nuclear morphology and potentially the function of Nup43. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Affects the mTOR pathway, which has roles in various cellular processes, potentially influencing NPC and Nup43 indirectly. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
A calcium ionophore, influencing calcium signaling which may indirectly impact NPC function and Nup43. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Inhibits protein phosphatases, potentially influencing the phosphorylation status and function of nucleoporins like Nup43. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
A PI3K inhibitor; given the broad roles of PI3K in cell signaling, it may indirectly influence Nup43's function in the NPC. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
Another PI3K inhibitor; can modulate various cellular processes, potentially impacting Nup43 within the NPC | ||||||