Nup214 Inhibitors

Nup214 inhibitors are a class of chemical compounds designed to target and modulate the activity of Nucleoporin 214 (Nup214), a protein that plays a crucial role in the structure and function of the nuclear pore complex (NPC). The nuclear pore complex is a large protein assembly that spans the nuclear envelope and serves as the gateway for the transport of macromolecules, including proteins and RNAs, between the nucleus and the cytoplasm. Nup214 is one of the nucleoporins that make up the NPC and is located on the cytoplasmic face of the complex. It functions in nucleocytoplasmic transport, allowing the selective passage of specific cargoes while maintaining the integrity of the nuclear envelope. Inhibitors of Nup214 activity can be valuable tools for researchers studying the dynamics and regulation of nucleocytoplasmic transport and the structure of the nuclear pore complex. By modulating Nup214's function, these inhibitors can provide insights into the molecular mechanisms that govern the transport of macromolecules between the nucleus and cytoplasm. Additionally, the development of Nup214 inhibitors may have implications for various cellular processes and diseases where nucleocytoplasmic transport is dysregulated, such as certain types of cancer or viral infections. Therefore, Nup214 inhibitors represent an important area of research in cell biology and molecular medicine.