NUDT22 Inhibitors
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Allopurinol | 315-30-0 | sc-207272 | 25 g | $128.00 | ||
Allopurinol is a xanthine oxidase inhibitor that reduces the production of uric acid. NUDT22 is involved in purine metabolism, and inhibition of upstream purine degradation by allopurinol can lead to an accumulation of substrates that could indirectly inhibit NUDT22 activity by substrate competition. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
Methotrexate is a dihydrofolate reductase inhibitor, resulting in decreased synthesis of tetrahydrofolate and subsequently purine nucleotides. This reduction in purine synthesis can indirectly decrease NUDT22 activity by limiting its available substrates. | ||||||
6-Mercaptopurine | 50-44-2 | sc-361087 sc-361087A | 50 mg 100 mg | $71.00 $102.00 | ||
Mercaptopurine interferes with the synthesis and metabolism of purine nucleotides. By altering purine metabolism, mercaptopurine can reduce the availability of substrates for NUDT22, leading to decreased activity. | ||||||
Mycophenolic acid | 24280-93-1 | sc-200110 sc-200110A | 100 mg 500 mg | $68.00 $261.00 | 8 | |
Mycophenolic acid inhibits inosine monophosphate dehydrogenase, a key enzyme in the de novo synthesis of guanine nucleotides. This inhibition can lead to reduced guanine nucleotide levels, thereby potentially inhibiting NUDT22 activity due to lack of substrate. | ||||||
6-Thioguanine | 154-42-7 | sc-205587 sc-205587A | 250 mg 500 mg | $41.00 $53.00 | 3 | |
6-Thioguanine acts as a purine analog and inhibits several enzymes involved in purine metabolism. By mimicking purine bases, it can inhibit NUDT22 activity by competing for binding sites or incorporation into nucleotides. | ||||||
Ribavirin | 36791-04-5 | sc-203238 sc-203238A sc-203238B | 10 mg 100 mg 5 g | $62.00 $108.00 $210.00 | 1 | |
Ribavirin is a nucleoside analog that inhibits inosine monophosphate dehydrogenase. It reduces guanine nucleotide synthesis, which could result in decreased NUDT22 activity due to a reduction in substrate availability. | ||||||
Tiazofurin | 60084-10-8 | sc-475805 | 5 mg | $440.00 | ||
Tiazofurin inhibits the enzyme IMP dehydrogenase, leading to decreased levels of guanine nucleotides. Lower guanine nucleotide levels can result in indirect inhibition of NUDT22 activity. | ||||||
Acyclovir | 59277-89-3 | sc-202906 sc-202906A | 50 mg 500 mg | $147.00 $922.00 | 2 | |
Acyclovir, a guanosine analog, is phosphorylated to its active form in cells infected with herpes simplex virus. While targeting viral DNA polymerase, it could compete with guanosine, potentially reducing NUDT22 activity by substrate competition. | ||||||
Clofarabine | 123318-82-1 | sc-278864 sc-278864A | 10 mg 50 mg | $185.00 $781.00 | ||
Clofarabine is a purine nucleoside analog that inhibits ribonucleotide reductase and DNA polymerase. This inhibition can lead to a decrease in deoxynucleotide pools, indirectly inhibiting NUDT22 by reducing its substrate availability. | ||||||
Fludarabine | 21679-14-1 | sc-204755 sc-204755A | 5 mg 25 mg | $57.00 $200.00 | 15 | |
Fludarabine is a fluorinated nucleotide analog of adenosine that inhibits DNA synthesis. It can decrease the availability of adenosine nucleotides and thus indirectly inhibit NUDT22 activity. | ||||||