NPY4-R Activators

Chemical activators of NPY4-R include a variety of compounds that engage with this receptor to initiate a cascade of biological responses. Pancreatic Polypeptide, a natural agonist of NPY4-R, binds directly to the receptor, enabling its role in controlling gut motility and the secretion of pancreatic enzymes. Similarly, the synthetic peptide BVD-10 acts as a small-molecule agonist, directly interacting with NPY4-R to exert influence on physiological functions such as the regulation of food intake. Analog peptides like [Leu31, Pro34]NPY also target NPY4-R and are known to activate it, subsequently affecting energy homeostasis. Continuing with the chemical activators, Ac-RYYRWK-NH2, a hexapeptide analog of neuropeptide FF, activates NPY4-R, triggering signal transduction pathways that are associated with appetite control and energy balance. BIBO3304 and GR231118, while functioning as antagonists at other neuropeptide receptors, have been reported to activate NPY4-R, suggesting a unique and selective activation pattern that targets this receptor. Additionally, JNJ-31020028, primarily an antagonist at NPY2-R, may evoke an agonistic effect on NPY4-R, leading to receptor activation. Lastly, LY-255582, which is an antagonist at NPY1-R, has been reported to functionally activate NPY4-R, highlighting the complex interaction dynamics that can occur between different ligands and the receptor, leading to its activation and subsequent biological responses.