Date published: 2025-9-10

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NPFF1 Receptor Inhibitors

NPFF1 receptor inhibitors are a class of chemical compounds that target and modulate the activity of the NPFF1 receptor, a specific subtype of the Neuropeptide FF (NPFF) receptor family. These receptors are part of the G-protein coupled receptor (GPCR) superfamily and are primarily found in the central nervous system (CNS) and peripheral tissues. The NPFF1 receptor, in particular, plays a crucial role in regulating various physiological processes, including pain perception, stress response, appetite regulation, and cardiovascular function. Inhibitors of the NPFF1 receptor are designed to interact with this receptor, either blocking or reducing its activation by endogenous neuropeptides, such as NPAF and NPVF, or other ligands, thereby influencing the downstream signaling pathways associated with this receptor subtype. NPFF1 receptor inhibitors can encompass a diverse range of compounds, including small molecules and peptides, designed to specifically target the NPFF1 receptor and modulate its activity. These inhibitors may act through various mechanisms, such as competitive binding to the receptor's active site or allosteric modulation, leading to decreased receptor activation or signal transduction. By interfering with the NPFF1 receptor's function, these inhibitors have the potential to provide valuable insights into the physiological roles of the NPFF1 receptor and its associated pathways.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

RF9

876310-60-0sc-253428
1 mg
$150.00
(0)

RF9 exhibits unique interactions with the NPFF1 receptor, characterized by its ability to induce conformational changes that inhibit receptor activation. The compound's structural features facilitate specific hydrogen bonding and hydrophobic interactions, enhancing its selectivity. Additionally, RF9's kinetic profile suggests a rapid onset of action, allowing for transient modulation of receptor-mediated pathways. Its distinct physicochemical properties contribute to its effectiveness in altering neuropeptide signaling dynamics.

RF9 Trifluoroacetate salt

876310-60-0 (non-salt)sc-391110
5 mg
$300.00
1
(0)

RF9 Trifluoroacetate salt demonstrates a remarkable affinity for the NPFF1 receptor, engaging in intricate molecular interactions that stabilize the receptor in an inactive conformation. Its trifluoroacetate moiety enhances solubility and promotes unique electrostatic interactions, which fine-tune receptor binding. The compound's dynamic behavior in solution suggests a nuanced balance between hydrophilicity and lipophilicity, influencing its interaction kinetics and overall receptor modulation.

L-NG-Nitroarginine Methyl Ester (L-NAME)

51298-62-5sc-200333
sc-200333A
sc-200333B
1 g
5 g
25 g
$47.00
$105.00
$322.00
45
(1)

L-NAME is a nitric oxide synthase inhibitor, which can modulate nociceptive signaling involving NPFF1.

PD 98059

167869-21-8sc-3532
sc-3532A
1 mg
5 mg
$39.00
$90.00
212
(2)

PD 98059 is an inhibitor of MEK, which can have downstream effects on signaling pathways involving NPFF1.

SB 203580

152121-47-6sc-3533
sc-3533A
1 mg
5 mg
$88.00
$342.00
284
(5)

SB-203580 is a p38 MAP kinase inhibitor, potentially influencing inflammatory signaling related to NPFF1.

Y-27632, free base

146986-50-7sc-3536
sc-3536A
5 mg
50 mg
$182.00
$693.00
88
(1)

Y-27632 is a ROCK inhibitor, which can affect pain and nociceptive processing linked to NPFF1.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$121.00
$392.00
148
(1)

LY294002 is a PI3K inhibitor, which could affect various signaling pathways including those involving NPFF1.

PP 2

172889-27-9sc-202769
sc-202769A
1 mg
5 mg
$92.00
$223.00
30
(1)

PP2 is an Src family kinase inhibitor, which may indirectly influence NPFF1 receptor signaling.