NMDAε3 Activators
The chemical class of NMDAε3 Activators comprises various compounds that indirectly influence the activity of NMDAε3, a component of the NMDA receptor crucial in neuronal signaling and synaptic plasticity. These chemicals are integral to understanding the nuanced regulation of synaptic transmission and the specific functions of receptor subunits like NMDAε3.
Co-agonists such as glycine and D-serine are essential for NMDA receptor activation, and their binding facilitates the receptor's function, indirectly affecting NMDAε3. The modulation of NMDA receptor activity by ions like magnesium and zinc, which act as natural blockers or allosteric modulators, plays a significant role in the receptor's functioning and, consequently, the activity of NMDAε3. Polyamines like spermine also exemplify the receptor's sensitivity to chemical modulation, enhancing its function and indirectly impacting NMDAε3. NMDA receptor antagonists, including phencyclidine (PCP), ketamine, memantine, ifenprodil, and MK-801, provide insights into the receptor's functioning and NMDAε3's role. By interacting with different sites on the receptor, these compounds help elucidate the complex mechanisms of receptor activation and inhibition.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Glycine | 56-40-6 | sc-29096A sc-29096 sc-29096B sc-29096C | 500 g 1 kg 3 kg 10 kg | $41.00 $71.00 $112.00 $357.00 | 15 | |
As a co-agonist of NMDA receptors, glycine binding is necessary for receptor activation. Glycine supplementation can enhance NMDA receptor function, indirectly influencing NMDAε3 activity. | ||||||
D-Serine | 312-84-5 | sc-391671 sc-391671A sc-391671B | 5 g 25 g 100 g | $43.00 $128.00 $204.00 | ||
Acts similarly to glycine as a co-agonist of NMDA receptors. D-serine binding to the glycine site on the NMDA receptor can facilitate receptor activation, potentially influencing NMDAε3. | ||||||
Magnesium sulfate anhydrous | 7487-88-9 | sc-211764 sc-211764A sc-211764B sc-211764C sc-211764D | 500 g 1 kg 2.5 kg 5 kg 10 kg | $46.00 $69.00 $163.00 $245.00 $418.00 | 3 | |
Magnesium ions block NMDA receptors at rest. Modulating magnesium levels can influence NMDA receptor activity, indirectly affecting NMDAε3. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc modulates NMDA receptor activity by binding to a specific site on the receptor, which can indirectly influence NMDAε3 activity. | ||||||
Spermine | 71-44-3 | sc-212953A sc-212953 sc-212953B sc-212953C | 1 g 5 g 25 g 100 g | $61.00 $196.00 $277.00 $901.00 | 1 | |
Polyamines like spermine can modulate NMDA receptor activity. Their interaction with the receptor can enhance its function, indirectly affecting NMDAε3. | ||||||
(−)-Huperzine A | 102518-79-6 | sc-200183 sc-200183A | 1 mg 5 mg | $143.00 $362.00 | 1 | |
An inhibitor of acetylcholinesterase, huperzine A can increase acetylcholine levels, which may indirectly modulate NMDA receptor activity and hence NMDAε3. | ||||||
Sodium nitroprusside dihydrate | 13755-38-9 | sc-203395 sc-203395A sc-203395B | 1 g 5 g 100 g | $43.00 $85.00 $158.00 | 7 | |
Nitric oxide can modulate NMDA receptor activity. Donors like sodium nitroprusside, which release nitric oxide, can indirectly influence NMDAε3 through this pathway. | ||||||