nm23-H5 Activators
The nm23-H5 activators involve a range of compounds that can enhance the functionality of nm23-H5 through various pathways. For instance, AICAR, an AMPK activator, enhances the functional activity of nm23-H5 by activating AMPK, a protein that directly interacts with nm23-H5. Forskolin, an activator of adenylate cyclase, influences the functionality of nm23-H5 by raising cAMP levels, which then activates PKA, a protein known to interact with nm23-H5. Additionally, H-89, a PKA inhibitor, enhances the functional activity of nm23-H5 by inhibiting PKA, which is known to possibly inhibit nm23-H5. D4476, a Casein Kinase 1 (CK1) inhibitor, enhances the functionality of nm23-H5 by inhibiting CK1, a kinase that regulates nm23-H5 through phosphorylation.
A variety of other compounds can also enhance the functionality of nm23-H5 by targeting associated pathways. For example, LY294002, a PI3K inhibitor, enhances the functional activity of nm23-H5 by inhibiting PI3K, which is known to regulate nm23-H5. Furthermore, Rapamycin, an mTOR inhibitor, and U0126, an ERK inhibitor, enhance the functional activity of nm23-H5 by inhibiting the mTOR pathway and ERK respectively. Both pathways are known to interact with nm23-H5. Other examples include PD98059, a MEK inhibitor, and Staurosporine, a non-selective protein kinase inhibitor, which enhance the functional activity of nm23-H5 by inhibiting MEK and multiple protein kinases respectively. Cyclosporin A inhibits calcineurin, a phosphatase that acts on nm23-H5, thereby enhancing its functional activity. Lastly, Ionomycin enhances the functional activity of nm23-H5 by increasing intracellular calcium levels, which can trigger signaling events leading to its activation.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR is an AMPK activator. AMPK has been demonstrated to interact with nm23-H5 to modulate its activity. By activating AMPK, AICAR enhances the functional activity of nm23-H5. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is an activator of adenylate cyclase, raising cAMP levels. Elevated cAMP can influence the functional activity of nm23-H5 by activating PKA, which is known to interact with nm23-H5. | ||||||
Casein Kinase I Inhibitor, D4476 | 301836-43-1 | sc-202522 | 1 mg | $97.00 | 6 | |
D4476 is a Casein Kinase 1 (CK1) inhibitor. CK1 can regulate nm23-H5 through phosphorylation. By inhibiting CK1, D4476 can enhance the functional activity of nm23-H5. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor. PI3K is associated with the regulation of nm23-H5. By inhibiting PI3K, LY294002 can enhance the functional activity of nm23-H5. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor. The mTOR pathway can interact with nm23-H5. By inhibiting mTOR, Rapamycin can enhance the functional activity of nm23-H5. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor. MEK can regulate nm23-H5 through the MAPK pathway, which influences the phosphorylation of nm23-H5. By inhibiting MEK, PD98059 can enhance the functional activity of nm23-H5. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a non-selective protein kinase inhibitor. Protein kinases can regulate nm23-H5 through phosphorylation. By inhibiting these kinases, Staurosporine can enhance the functional activity of nm23-H5. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Cyclosporin A is an inhibitor of calcineurin, a phosphatase that acts on multiple proteins, including nm23-H5. By inhibiting calcineurin, Cyclosporin A can enhance the functional activity of nm23-H5. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor. Tyrosine kinases can regulate nm23-H5 through phosphorylation. By inhibiting these kinases, Genistein can enhance the functional activity of nm23-H5. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $94.00 $259.00 | 2 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. This rise in calcium levels can trigger signaling events that ultimately enhance the functional activity of nm23-H5. | ||||||