NKG2-C Inhibitors
NKG2-C inhibitors are a class of chemical compounds designed to modulate the activity of the NKG2-C receptor, a member of the natural killer (NK) cell receptor family. The NKG2-C receptor is an activating receptor found on the surface of NK cells and certain T cells, where it forms a complex with the CD94 molecule. This receptor specifically recognizes human leukocyte antigen-E (HLA-E), a non-classical MHC class I molecule, presented on the surface of target cells. Upon binding to HLA-E, the NKG2-C receptor transmits activating signals that lead to the cytotoxic response of NK cells, including the release of cytotoxic granules and cytokines, which are key components of the immune system's ability to target and eliminate cells that are stressed, infected, or otherwise abnormal.
The inhibition of NKG2-C activity by these compounds typically involves disrupting the interaction between the NKG2-C receptor and HLA-E, thereby preventing the downstream signaling cascade that leads to NK cell activation. This can be achieved through various mechanisms, such as direct binding to the receptor or its associated signaling molecules, which blocks the receptor's ability to recognize and bind HLA-E. Alternatively, inhibitors might prevent the assembly or stability of the NKG2-C/CD94 complex on the cell surface, thereby reducing its functional expression. NKG2-C inhibitors are important tools for researchers studying the regulation of NK cell activity and the intricate balance between activation and inhibition within the immune system. By modulating this specific pathway, scientists can gain insights into how NK cells discriminate between healthy and abnormal cells, as well as the broader mechanisms governing immune surveillance and the maintenance of immune homeostasis.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
Through the incorporation into genomic DNA, 5-Azacytidine could lead to the demethylation of the KLRC2 gene promoter, potentially resulting in suppressed transcription and reduced NKG2-C protein synthesis. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
5-Aza-2′-Deoxycytidine may target DNA methyltransferases, specifically causing demethylation of the KLRC2 gene's promoter region, which could result in a decrease in NKG2-C mRNA and subsequent protein levels. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic Acid has the potential to inhibit histone deacetylases, which might result in hyperacetylation of histones near the KLRC2 gene, leading to the constriction of chromatin and a consequent decrease in NKG2-C expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
By specifically inhibiting histone deacetylase activity, Trichostatin A could induce hyperacetylation of histones at the KLRC2 gene, which may result in a transcriptionally inactive chromatin state and diminished NKG2-C protein levels. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium Butyrate could inhibit histone deacetylase, leading to enhanced acetylation of histones associated with the KLRC2 gene, potentially resulting in the tightening of chromatin structure and the subsequent downregulation of NKG2-C production. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
Mithramycin A can bind to specific DNA sequences, possibly obstructing transcription factor access to the KLRC2 gene promoter, which may lead to a decrease in NKG2-C mRNA transcription. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin may directly inhibit the activity of specific transcription factors responsible for the upregulation of the KLRC2 gene, potentially leading to reduced levels of NKG2-C protein. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol might exert inhibitory effects on the activity of transcription factors or coactivators essential for the expression of the KLRC2 gene, potentially resulting in decreased synthesis of the NKG2-C protein. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
DL-Sulforaphane could promote the hyperacetylation of histones at the KLRC2 gene locus, which may cause chromatin remodeling and a subsequent decrease in NKG2-C expression. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Disulfiram may indirectly lead to the reduction of NKG2-C expression by chelating metal ions necessary for the proper function of transcription factors involved in the upregulation of the KLRC2 gene. | ||||||