NHP2 Inhibitors
NHP2 Inhibitors, primarily, target processes that are upstream of the specific functions carried out by NHP2. A primary method involves the inhibition of RNA synthesis and ribosomal biogenesis, given that NHP2 has a significant role in rRNA processing. Chemicals like Actinomycin D and CX-5461 directly target RNA synthesis, affecting the overall output of rRNA. Additionally, compounds such as 5-FU are integrated into RNA, disrupting its normal processing and function, thereby indirectly influencing NHP2's role in RNA modification.
Another prevalent strategy is the targeted inhibition of specific RNA polymerases. Molecules like α-amanitin inhibit RNA polymerase II, while Relacin and DRB target RNA polymerase I. Given the interconnected nature of RNA synthesis and processing pathways, these inhibitors can modulate various RNA processes, including those where NHP2 plays a role. The cumulative impact of these inhibitors ensures the control of NHP2's functions, either by directly influencing the pathways it's involved in or by affecting upstream processes that lead to its activation.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Binds to DNA and inhibits RNA synthesis, affecting ribosomal biogenesis. Can indirectly influence NHP2 function associated with rRNA processing. | ||||||
CX-5461 | 1138549-36-6 | sc-507275 | 5 mg | $245.00 | ||
Inhibits RNA polymerase I, crucial for rRNA synthesis, which can indirectly affect NHP2 function in ribosome biogenesis. | ||||||
BMH-21 | 896705-16-1 | sc-507460 | 10 mg | $165.00 | ||
Binds to rDNA and inhibits RNA polymerase I, potentially affecting NHP2's role in ribosomal RNA processing. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
Incorporates into RNA, disrupting processing and function. It can influence pathways where NHP2 is involved, especially in RNA modification. | ||||||
Thiolutin | 87-11-6 | sc-200387 sc-200387A | 1 mg 5 mg | $101.00 $406.00 | 1 | |
An inhibitor of RNA polymerase, impacting RNA synthesis. This can indirectly affect NHP2-associated processes. | ||||||
Mycophenolic acid | 24280-93-1 | sc-200110 sc-200110A | 100 mg 500 mg | $69.00 $266.00 | 8 | |
Inhibits inosine monophosphate dehydrogenase, affecting guanine nucleotide synthesis and thereby RNA synthesis. This can impact NHP2's role in RNA processing. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
Specifically inhibits RNA polymerase II. This inhibition can have downstream effects on processes where NHP2 is involved. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $43.00 $189.00 $316.00 $663.00 | 6 | |
Inhibits RNA polymerase II, affecting RNA synthesis and indirectly influencing NHP2-associated pathways. | ||||||
Acivicin | 42228-92-2 | sc-200498B sc-200498C sc-200498 sc-200498D | 1 mg 5 mg 10 mg 25 mg | $104.00 $416.00 $655.00 $1301.00 | 10 | |
Inhibits enzymes involved in nucleotide biosynthesis, potentially affecting RNA-related processes where NHP2 is a participant. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Inhibits DNA topoisomerase I, which can indirectly influence RNA synthesis and potentially processes where NHP2 is involved. | ||||||