NGF Activators
The NGF activators comprise a diverse group of chemicals that have the ability to influence the expression and activity of nerve growth factor (NGF), a pivotal neurotrophic factor involved in the development, survival, and function of neurons. These activators include compounds such as TrkA agonists, Aniracetam, Huperzine A, Uridine, Bacopa monnieri extract, Lithium, EGCG, Lion's Mane Mushroom extract, N-acetylcysteine (NAC), Tauroursodeoxycholic acid (TUDCA), Sulforaphane, and Curcumin, each with distinct mechanisms of action. TrkA agonists directly activate the TrkA receptor, a high-affinity receptor for NGF, mimicking the effects of NGF itself. Aniracetam and Huperzine A exert their influence through cholinergic neurotransmission, with Aniracetam enhancing acetylcholine release and Huperzine A inhibiting acetylcholinesterase, leading to increased acetylcholine levels. Uridine, a nucleoside, may impact NGF levels through its involvement in nucleotide biosynthesis, contributing to the overall regulation of neurotrophic factor synthesis.
Natural compounds, including Bacopa monnieri extract, Lion's Mane Mushroom extract, EGCG, NAC, TUDCA, Sulforaphane, and Curcumin, showcase the ability of dietary components to modulate NGF levels. These compounds operate through diverse mechanisms, including antioxidant and anti-inflammatory properties, interactions with signaling pathways related to neurotrophic factor synthesis, and the modulation of cellular homeostasis. The intricate interplay between these chemicals and NGF reflects the multifaceted nature of neurotrophic regulation. While some compounds directly activate NGF receptors or influence cholinergic neurotransmission, others exert their effects indirectly through antioxidant, anti-inflammatory, and cellular homeostasis mechanisms. The diversity within the NGF activators highlights the ability of these compounds to contribute to our understanding of neurotrophic signaling and provides avenues for exploring natural and pharmacological interventions in neurological health.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Aniracetam | 72432-10-1 | sc-203514 sc-203514A | 50 mg 250 mg | $113.00 $447.00 | ||
Aniracetam is a nootropic compound that may indirectly influence NGF levels by modulating cholinergic neurotransmission. It has been suggested that Aniracetam enhances the release of acetylcholine, and increased cholinergic activity has been associated with elevated NGF levels. The detailed mechanism involves the interaction of Aniracetam with cholinergic receptors, potentially leading to an upregulation of NGF expression. | ||||||
Uridine | 58-96-8 | sc-296685 sc-296685A | 1 g 25 g | $60.00 $98.00 | 1 | |
Uridine is a nucleoside that may impact NGF levels through its involvement in nucleotide biosynthesis. Uridine is a precursor for the synthesis of RNA and is implicated in cellular processes related to neurotrophic factor production. While the direct interaction with NGF may not be established, Uridine's role in nucleotide metabolism suggests a potential indirect influence on NGF expression. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium, primarily known for its use in bipolar disorder treatment, has been suggested to influence NGF expression. While the exact mechanism remains unclear, Lithium may impact intracellular signaling cascades associated with neurotrophic factor synthesis. The modulation of glycogen synthase kinase-3 (GSK-3) and other signaling molecules by Lithium provides potential links to NGF expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, a polyphenol found in green tea, has been proposed to influence NGF levels through its antioxidant and anti-inflammatory properties. The detailed mechanisms involve interactions with cellular pathways associated with neurotrophic factor production. EGCG's ability to modulate oxidative stress and inflammation may contribute to the upregulation of NGF expression. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $33.00 $73.00 $265.00 $112.00 | 34 | |
NAC is a precursor to glutathione, a crucial antioxidant in cells. While the direct interaction with NGF may not be fully elucidated, NAC's antioxidant properties suggest an indirect influence on neurotrophic factor regulation. By reducing oxidative stress, NAC may contribute to the preservation of NGF levels and the overall neurotrophic milieu. | ||||||
Tauroursodeoxycholic Acid, Sodium Salt | 14605-22-2 | sc-281165 | 1 g | $644.00 | 5 | |
TUDCA, a bile acid derivative, has been associated with neuroprotective effects and may impact NGF levels. While specific CAS numbers for TUDCA may be available, its detailed mechanism involves interactions with cellular pathways related to neurotrophic factor production. TUDCA's ability to modulate endoplasmic reticulum (ER) stress and maintain cellular homeostasis suggests potential indirect effects on NGF expression. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane, a compound found in cruciferous vegetables, has been proposed to influence NGF levels through its anti-inflammatory and antioxidant properties. The detailed mechanisms involve interactions with cellular pathways associated with neurotrophic factor production. Sulforaphane's ability to modulate inflammatory responses and oxidative stress may contribute to the upregulation of NGF expression. components and neurotrophic signaling. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, a polyphenol in turmeric, has been proposed to influence NGF levels through its anti-inflammatory and antioxidant properties. The detailed mechanisms involve interactions with cellular pathways associated with neurotrophic factor production. Curcumin's ability to modulate inflammatory responses and oxidative stress may contribute to the upregulation of NGF expression. | ||||||