neuroligin X/Y Inhibitors

The chemical class of neuroligin X/Y Inhibitors encompasses a diverse range of small molecules that target various signaling pathways and cellular processes involved in the regulation of neuroligin X/Y expression and function. These inhibitors act on different molecular targets, including enzymes such as histone deacetylases (HDACs), kinases like Janus kinases (JAKs) and glycogen synthase kinase 3 (GSK-3), receptors such as vascular endothelial growth factor receptor (VEGFR) and transforming growth factor beta (TGF-β) receptor, and other proteins like guanine nucleotide exchange factors (GEFs) and proteasome.

The inhibition of these targets can modulate neuroligin X/Y levels, synaptic plasticity, and neuronal function. For example, inhibitors of HDACs, such as MS-275 and CUDC-907, can alter the transcriptional regulation of genes involved in neuroligin X/Y signaling pathways. Similarly, compounds like Ruxolitinib and SB216763 target kinases that play crucial roles in neuroligin X/Y-mediated cellular responses. Additionally, inhibitors of growth factor receptors like Axitinib and Sunitinib can indirectly influence neuroligin X/Y expression through modulation of downstream signaling cascades. Overall, neuroligin X/Y inhibitors represent a valuable tool for studying the molecular mechanisms underlying synaptic function.