Date published: 2026-5-7

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NDUFA5 Inhibitors

NDUFA5 inhibitors comprise a range of compounds targeting various components of mitochondrial function and cellular metabolism. Rotenone and Piericidin A act as mitochondrial complex I inhibitors, indirectly influencing NDUFA5 by disrupting electron transport in the respiratory chain, leading to alterations in ATP production and potentially affecting NDUFA5 expression and function within the context of oxidative phosphorylation. Metformin, a well-known AMP-activated protein kinase (AMPK) activator, indirectly influences NDUFA5 by activating AMPK and altering cellular energy homeostasis. This modulation impacts NDUFA5 expression and function by influencing AMPK-mediated pathways, providing a potential link between NDUFA5 and cellular responses associated with energy balance and metabolic regulation. Malonate, a succinate dehydrogenase inhibitor, indirectly affects NDUFA5 by disrupting the tricarboxylic acid cycle and influencing mitochondrial function. This modulation impacts NDUFA5 expression and function by altering the metabolic flux through the electron transport chain, potentially linking NDUFA5 to processes associated with cellular bioenergetics. Atractyloside, an adenine nucleotide translocase inhibitor, indirectly influences NDUFA5 by disrupting mitochondrial membrane permeability and affecting ATP production. This modulation impacts NDUFA5 by altering the cellular environment, potentially influencing its expression and function within the context of mitochondrial bioenergetics. Antimycin A, a mitochondrial complex III inhibitor, indirectly affects NDUFA5 by disrupting the respiratory chain and leading to decreased ATP synthesis. This modulation influences NDUFA5 expression and function by perturbing the electron transport system, potentially impacting its involvement in mitochondrial bioenergetics. FCCP (Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone), another mitochondrial uncoupler, indirectly influences NDUFA5 by disrupting the proton gradient and affecting ATP synthesis. This modulation impacts NDUFA5 by altering mitochondrial membrane potential, potentially influencing its involvement in electron transport and oxidative phosphorylation processes. Rhodamine 123, a mitochondrial membrane potential uncoupler, indirectly affects NDUFA5 by disrupting the proton gradient and affecting ATP synthesis. This modulation impacts NDUFA5 by altering mitochondrial membrane potential, potentially influencing its involvement in electron transport and oxidative phosphorylation processes.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Rotenone

83-79-4sc-203242
sc-203242A
1 g
5 g
$89.00
$259.00
41
(2)

Mitochondrial complex I inhibitor indirectly influencing NDUFA5. Rotenone disrupts electron transport in the respiratory chain, affecting ATP production. This modulation impacts NDUFA5 by altering the electron flow, potentially leading to changes in its expression and function within the context of oxidative phosphorylation.

Piericidin A

2738-64-9sc-202287
2 mg
$291.00
24
(1)

Mitochondrial complex I inhibitor indirectly affecting NDUFA5. Piericidin A disrupts the respiratory chain, leading to decreased ATP synthesis. This modulation influences NDUFA5 expression and function by perturbing the electron transport system, potentially impacting its involvement in mitochondrial bioenergetics.

Coenzyme Q10

303-98-0sc-205262
sc-205262A
1 g
5 g
$71.00
$184.00
1
(1)

Ubiquinone is another electron carrier in the mitochondrial electron transport chain. It interacts with NDUFA5 and is involved in the transfer of electrons within complex I.

Metformin

657-24-9sc-507370
10 mg
$79.00
2
(0)

AMP-activated protein kinase (AMPK) activator indirectly influencing NDUFA5. Metformin activates AMPK, altering cellular energy homeostasis. This modulation impacts NDUFA5 expression and function by influencing AMPK-mediated pathways, potentially linking NDUFA5 to cellular responses associated with energy balance and metabolic regulation.

2-Deoxy-D-glucose

154-17-6sc-202010
sc-202010A
1 g
5 g
$70.00
$215.00
26
(2)

Glycolysis inhibitor indirectly affecting NDUFA5. 2-Deoxyglucose disrupts glucose metabolism, altering cellular ATP levels. This modulation impacts NDUFA5 expression and function by influencing the availability of substrates for mitochondrial oxidative phosphorylation, potentially linking NDUFA5 to cellular responses associated with altered energy metabolism.

Carbonyl Cyanide m-Chlorophenylhydrazone

555-60-2sc-202984A
sc-202984
sc-202984B
100 mg
250 mg
500 mg
$77.00
$153.00
$240.00
8
(1)

Mitochondrial uncoupler indirectly influencing NDUFA5. CCCP disrupts the proton gradient, affecting ATP synthesis. This modulation impacts NDUFA5 expression and function by altering mitochondrial membrane potential, potentially influencing its involvement in electron transport and oxidative phosphorylation processes.

Oligomycin A

579-13-5sc-201551
sc-201551A
sc-201551B
sc-201551C
sc-201551D
5 mg
25 mg
100 mg
500 mg
1 g
$179.00
$612.00
$1203.00
$5202.00
$9364.00
26
(1)

ATP synthase inhibitor indirectly affecting NDUFA5. Oligomycin A disrupts oxidative phosphorylation, affecting ATP production. This modulation impacts NDUFA5 by altering the cellular ATP levels, potentially influencing its expression and function within the context of mitochondrial bioenergetics.

AICAR

2627-69-2sc-200659
sc-200659A
sc-200659B
50 mg
250 mg
1 g
$65.00
$280.00
$400.00
48
(2)

AMP-activated protein kinase (AMPK) activator indirectly influencing NDUFA5. AICAR activates AMPK, altering cellular energy homeostasis. This modulation impacts NDUFA5 expression and function by influencing AMPK-mediated pathways, potentially linking NDUFA5 to cellular responses associated with energy balance and metabolic regulation.

Antimycin A

1397-94-0sc-202467
sc-202467A
sc-202467B
sc-202467C
5 mg
10 mg
1 g
3 g
$55.00
$63.00
$1675.00
$4692.00
51
(1)

Mitochondrial complex III inhibitor indirectly affecting NDUFA5. Antimycin A disrupts the respiratory chain, leading to decreased ATP synthesis. This modulation influences NDUFA5 expression and function by perturbing the electron transport system, potentially impacting its involvement in mitochondrial bioenergetics.

FCCP

370-86-5sc-203578
sc-203578A
10 mg
50 mg
$94.00
$355.00
46
(1)

Mitochondrial uncoupler indirectly influencing NDUFA5. FCCP disrupts the proton gradient, affecting ATP synthesis. This modulation impacts NDUFA5 expression and function by altering mitochondrial membrane potential, potentially influencing its involvement in electron transport and oxidative phosphorylation processes.