NCX2 Activators
NCX2 activators represent a diverse array of chemicals that exert their activating effects on the sodium-calcium exchanger 2 (NCX2) through specific and intricate cellular pathways. Bay K8644, a calcium channel activator, directly activates NCX2 by enhancing calcium influx through L-type calcium channels. This direct modulation of NCX2 illustrates the specificity of Bay K8644 in influencing calcium-dependent cellular processes. Compounds like Nitrendipine and Nifedipine, dihydropyridine calcium channel blockers, indirectly activate NCX2 by reducing intracellular calcium levels. The compensatory upregulation of NCX2 activity in response to decreased intracellular calcium highlights the intricate relationship between calcium signaling and NCX2 function. Dantrolene, a muscle relaxant, indirectly influences NCX2 by modulating calcium release from the sarcoplasmic reticulum, emphasizing the indirect modulation of NCX2 through calcium handling mechanisms.
Gambogic acid, a natural product, activates NCX2 through the modulation of intracellular calcium levels. The direct impact of gambogic acid on intracellular calcium concentrations illustrates its role as a specific activator of NCX2 through the regulation of calcium homeostasis. (-)-Epicatechin, a flavonoid, indirectly activates NCX2 by influencing the eNOS pathway, suggesting a connection between vascular signaling pathways and NCX2 activity. Rosmarinic acid, a polyphenolic compound, activates NCX2 by modulating the MAPK pathway, showcasing its impact on the intricate network of pathways involved in NCX2 regulation. Ascorbic acid (Vitamin C), a potent antioxidant, indirectly activates NCX2 by influencing the redox state of the cell. The indirect activation of NCX2 through redox modulation underscores the potential link between cellular antioxidant status and the functional regulation of NCX2. Sodium nitroprusside, a nitric oxide donor, activates NCX2 through the generation of nitric oxide (NO). The direct activation of NCX2 through NO generation highlights the specific role of nitric oxide signaling in modulating NCX2 activity, showcasing the potential impact of vasodilatory pathways on NCX2 regulation.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $82.00 $192.00 $801.00 | ||
Bay K8644 is a calcium channel activator that enhances Ca2+ influx through L-type calcium channels. By specifically targeting these channels, Bay K8644 increases intracellular calcium concentrations, leading to the activation of the sodium-calcium exchanger 2 (NCX2). The modulation of NCX2 by increased intracellular calcium levels serves as a direct mechanism through which Bay K8644 can activate NCX2, illustrating its role as a specific calcium channel activator. | ||||||
Anhydrovinblastine | 38390-45-3 | sc-358045 sc-358045A | 25 mg 100 mg | $510.00 $1428.00 | ||
Anhydrovinblastine is a vinca alkaloid that influences microtubule dynamics. Its impact on NCX2 activation is mediated through microtubule-dependent processes. By affecting microtubule stability, Anhydrovinblastine indirectly modulates NCX2 activity, suggesting a potential link between microtubule dynamics and NCX2 function. | ||||||
Nitrendipine | 39562-70-4 | sc-201466 sc-201466A sc-201466B | 50 mg 100 mg 500 mg | $107.00 $157.00 $449.00 | 6 | |
Nitrendipine is a dihydropyridine calcium channel blocker that indirectly activates NCX2. Its mechanism involves blocking L-type calcium channels, leading to decreased intracellular calcium concentrations. As a compensatory response, NCX2 activity is upregulated to maintain cellular calcium homeostasis. The indirect activation of NCX2 through the inhibition of L-type calcium channels highlights the intricate relationship between calcium signaling and NCX2 function. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $58.00 $170.00 | 15 | |
Nifedipine, similar to Nitrendipine, is a dihydropyridine calcium channel blocker. Its indirect activation of NCX2 is also attributed to the blockade of L-type calcium channels. By reducing intracellular calcium levels, Nifedipine triggers a compensatory increase in NCX2 activity, emphasizing the indirect modulation of NCX2 through the regulation of calcium homeostasis. | ||||||
Dantrolene | 7261-97-4 | sc-500165 | 25 mg | $350.00 | 7 | |
Dantrolene is a muscle relaxant that indirectly influences NCX2 by targeting the ryanodine receptor and inhibiting calcium release from the sarcoplasmic reticulum. | ||||||
N-Ethylmaleimide | 128-53-0 | sc-202719A sc-202719 sc-202719B sc-202719C sc-202719D | 1 g 5 g 25 g 100 g 250 g | $22.00 $68.00 $210.00 $780.00 $1880.00 | 19 | |
N-Ethylmaleimide indirectly activates NCX2 by influencing the redox state of the cell. As a thiol-reactive compound, N-Ethylmaleimide modifies cysteine residues, potentially affecting redox-sensitive signaling pathways that modulate NCX2 activity. The indirect activation of NCX2 through redox modulation highlights the intricate connection between cellular redox status and the functional regulation of NCX2. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a polyphenolic compound, indirectly activates NCX2 by modulating the sirtuin 1 (SIRT1) pathway. By activating SIRT1, resveratrol influences downstream pathways that may impact NCX2 function. The indirect activation of NCX2 through SIRT1 modulation underscores the potential link between cellular metabolism and NCX2 regulation. | ||||||
Gambogic Acid | 2752-65-0 | sc-200137 sc-200137A sc-200137B sc-200137C sc-200137D | 5 mg 25 mg 100 mg 500 mg 1 g | $85.00 $243.00 $419.00 $720.00 $1230.00 | 5 | |
Gambogic acid activates NCX2 through the modulation of intracellular calcium levels. As a natural product, gambogic acid induces changes in cellular calcium dynamics, leading to the activation of NCX2 as a compensatory response. The direct impact of gambogic acid on intracellular calcium concentrations illustrates its role as a specific activator of NCX2 through the regulation of calcium homeostasis. | ||||||
(−)Epicatechin | 490-46-0 | sc-205672 sc-205672A | 1 mg 5 mg | $50.00 $135.00 | ||
(-)-Epicatechin, a flavonoid, indirectly activates NCX2 by influencing the endothelial nitric oxide synthase (eNOS) pathway. Through eNOS activation, (-)-Epicatechin modulates nitric oxide production, which may impact NCX2 function. The indirect activation of NCX2 through eNOS modulation suggests a connection between vascular signaling pathways and NCX2 activity. | ||||||
Rosmarinic Acid | 20283-92-5 | sc-202796 sc-202796A | 10 mg 50 mg | $57.00 $107.00 | 4 | |
Rosmarinic acid activates NCX2 by modulating the mitogen-activated protein kinase (MAPK) pathway. As a polyphenolic compound, rosmarinic acid influences MAPK signaling, leading to increased NCX2 activity. The direct activation of NCX2 through MAPK modulation highlights rosmarinic acid as a specific activator, illustrating its impact on the intricate network of pathways involved in NCX2 regulation. | ||||||