NALP8 Activators
NALP8 Activators encompass a range of chemical compounds that bolster the functional activity of NALP8 through distinct signaling pathways, specifically those associated with the regulation of inflammation and immune response. Sulforaphane, curcumin, and epigallocatechin gallate (EGCG) each interact with different molecular targets that influence the Nrf2, NF-κB, and AMPK pathways, respectively, all known to play roles in managing oxidative stress and inflammation. The upregulation of anti-inflammatory pathways by these activators could indirectly enhance NALP8's role in mitigating inflammatory processes, without increasing its direct expression. Resveratrol, through activation of SIRT1, and omega-3 fatty acids, by modulating cytokine production, are believed to fine-tune the immune response, potentially providing an indirect uplift to NALP8's activity. Similarly, quercetin's antihistamine effect, alongside vitamin D3's immune response modulation, zinc's membrane stabilization, and berberine's AMPK pathway modulation, could collectively contribute to an environment that is conducive to NALP8's involvement in the immune system's regulatory mechanisms.
The array of NALP8 Activators also includes compounds like capsaicin, which activates TRPV1 receptors, and andrographolide, known for its inhibitory action on NF-κB activation; these substances further potentiate NALP8's activity by influencing the inflammatory signaling pathways. Piperine, another activator, inhibits enzymes that are implicated in the inflammatory process, thus reducing competition for NALP8 pathways and allowing for a more pronounced activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane activates the Nrf2 pathway, which regulates the expression of antioxidant proteins that protect against oxidative damage triggered by inflammation and injury. NALP8 is thought to be involved in inflammatory processes; thus, sulforaphane may enhance NALP8 activity indirectly by promoting an anti-inflammatory environment. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin influences multiple signaling pathways, including the inhibition of NF-κB. By inhibiting this pathway, curcumin could reduce inflammatory responses, potentially enhancing the activity of NALP8, which is involved in the regulation of inflammation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates SIRT1 which in turn deacetylates proteins involved in inflammatory response. Through this deacetylation process, NALP8 activity could be enhanced by modulating the inflammation in which NALP8 is implicated. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin inhibits the release of histamine and other inflammatory mediators, potentially increasing NALP8 activity indirectly by attenuating the inflammation that NALP8 is involved in regulating. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Vitamin D3 modulates the immune response and has been shown to influence the expression of genes involved in inflammation. It may enhance NALP8 activity by modulating the immune responses that NALP8 is part of. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc has a role in modulating the immune system and inflammatory response. It could indirectly enhance NALP8 activity by stabilizing cellular membranes and reducing inflammation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, a polyphenol found in green tea, has anti-inflammatory and antioxidant properties that could enhance NALP8 activity by attenuating the inflammatory pathways that NALP8 is thought to be involved in. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin activates TRPV1 receptors, which are involved in pain and inflammation signaling. This could indirectly enhance NALP8 activity by modulating the inflammation pathways in which NALP8 may play a role. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $90.00 | 1 | |
Berberine modulates the AMPK pathway, which is involved in cellular energy homeostasis and could indirectly influence NALP8 activity by affecting inflammatory pathways. | ||||||
Andrographolide | 5508-58-7 | sc-205594 sc-205594A | 50 mg 100 mg | $15.00 $39.00 | 7 | |
Andrographolide inhibits NF-κB activation, which may enhance NALP8 activity by attenuating the inflammatory responses regulated by NALP8. | ||||||