NaGLT1 Inhibitors
Chemical inhibitors of NaGLT1 include a variety of compounds that interfere with the protein's ability to transport glucose across cell membranes. Phlorizin and phloretin, for example, target the glucose-binding site on NaGLT1, preventing glucose from entering the cell. They achieve this by mimicking glucose molecules and competitively binding to the transport sites that would normally accommodate glucose. Consequently, these inhibitors effectively block the pathway glucose would take through NaGLT1, reducing its transport function. Similarly, dapagliflozin and canagliflozin, which are selective for SGLT2, can also bind to NaGLT1 due to the structural and functional similarities in their glucose-binding domains. By occupying these sites, they act as competitive antagonists to the natural substrate, glucose.
Other inhibitors such as empagliflozin and indinavir function by attaching to the active site or allosteric sites of NaGLT1, thereby altering the protein's conformation and hindering its glucose transport activity. WZB117 and STF-31, known for their inhibitory action on GLUT transporters, similarly inhibit NaGLT1 by binding to the glucose transport channels, which results in the obstruction of glucose uptake. Cytochalasin B, while primarily affecting actin filaments, also extends its inhibitory action to NaGLT1 by binding at the glucose transport site, thereby preventing the transporter from performing its role in glucose uptake. Flavonoids such as isoquercetin and quercetin inhibit NaGLT1 by directly interacting with the protein, which results in the disruption of its glucose transport function. These inhibitors employ a range of mechanisms, such as competitive inhibition at the binding site, to modulate the protein's activity without necessitating the presence of glucose.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Phloridzin dihydrate | 7061-54-3 | sc-215708 sc-215708A | 250 mg 1 g | $49.00 $119.00 | ||
Phlorizin is an inhibitor of SGLT1 and SGLT2, glucose transporters that share similarity with NaGLT1. It binds to the glucose-binding site, thus preventing glucose uptake into cells. As NaGLT1 is also a glucose transporter, Phlorizin can inhibit NaGLT1 by blocking its glucose transport function. | ||||||
Phloretin | 60-82-2 | sc-3548 sc-3548A | 200 mg 1 g | $64.00 $255.00 | 13 | |
Phloretin inhibits various glucose transporters, including GLUT family members, by interfering with the glucose transport mechanism. Since NaGLT1 functions similarly in glucose transport, Phloretin can inhibit NaGLT1 by impairing its ability to transport glucose across the cell membrane. | ||||||
Dapagliflozin | 461432-26-8 | sc-364481 sc-364481A sc-364481B | 5 mg 50 mg 1 g | $117.00 $428.00 $1051.00 | 6 | |
Dapagliflozin is an inhibitor of SGLT2, and due to structural and functional similarities with NaGLT1, it can inhibit NaGLT1 by competitively binding to its glucose-binding site, preventing glucose transport. | ||||||
Canagliflozin | 842133-18-0 | sc-364454 sc-364454A | 5 mg 50 mg | $312.00 $416.00 | 2 | |
Canagliflozin selectively inhibits SGLT2 over SGLT1, but can also inhibit NaGLT1 due to the conserved mechanism of action in glucose transport, by binding to the glucose transport channel. | ||||||
Empagliflozin | 864070-44-0 | sc-482194 sc-482194A sc-482194B sc-482194C | 1 g 5 g 10 g 100 g | $165.00 $322.00 $407.00 $1221.00 | 5 | |
Empagliflozin is an SGLT2 inhibitor that may inhibit NaGLT1 by binding to its glucose transport site, thereby competitively preventing glucose uptake. | ||||||
Indinavir | 150378-17-9 | sc-353630 | 100 mg | $982.00 | 1 | |
Indinavir is an HIV protease inhibitor that has been shown to bind and inhibit various proteins. It can inhibit NaGLT1 by binding to its active site or allosteric sites, resulting in a decrease in glucose transport activity. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $49.00 $124.00 $441.00 $828.00 | 4 | |
WZB117 is a glucose transporter inhibitor that blocks the uptake of glucose by binding to the glucose binding pockets of GLUT transporters. Given the similar glucose transport mechanism, WZB117 can inhibit NaGLT1 by blocking its glucose uptake function. | ||||||
STF 31 | 724741-75-7 | sc-364692 | 10 mg | $187.00 | 3 | |
STF-31 is known to inhibit GLUT1, which shares a functional role in glucose transport with NaGLT1. STF-31 can inhibit NaGLT1 by binding to the glucose transport channel, preventing glucose uptake. | ||||||
Cytochalasin B | 14930-96-2 | sc-3519 | 5 mg | $199.00 | 19 | |
Cytochalasin B disrupts actin filaments and can also inhibit glucose transporters by binding to their glucose transport site. This binding inhibits the function of NaGLT1 by blocking its ability to transport glucose. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid that inhibits a wide range of proteins and enzymes. It can inhibit NaGLT1 by binding to its active site, altering the protein conformation, and impeding its glucose transport function. | ||||||