NaBC1 Activators
NaBC1 activators encompass a range of chemical compounds that indirectly promote the functional activity of NaBC1 through diverse signaling pathways and cellular mechanisms. Compounds such as Forskolin and IBMX exert their effects by enhancing intracellular cAMP levels, with Forskolin activating adenylyl cyclase and IBMX inhibiting phosphodiesterases, respectively. The resultant elevation in cAMP can lead to the activation of PKA, which may phosphorylate proteins that modulate NaBC1's activity, resulting in an indirect enhancement of its function. Similarly, Sildenafil and Sodium Nitroprusside, by inhibiting PDE5 and donating nitric oxide respectively, increase cGMP levels, which could activate PKG, potentially leading to phosphorylation events that influence NaBC1. Anandamide and Capsaicin engage distinct receptors such as cannabinoid receptors and TRPV1, which initiate signaling cascades that can modulate ion channels and transporters, including NaBC1, through changes in intracellular calcium or membrane fluidity.
The activity of NaBC1 is further influenced by compounds that integrate into cellular membranes or modulate signal transduction. Omega-3 fatty acids like DHA alter membrane fluidity, which could affect the function of membrane proteins like NaBC1. Curcumin, through its effect on multiple cellular pathways, may change the cellular localization or interaction of NaBC1 with other proteins. Zinc ions, serving as cofactors, might modulate NaBC1 activity by affecting its structural conformation or interaction with other regulatory molecules. Verapamil, by blocking calcium channels, and Caffeine, through phosphodiesterase inhibition and adenosine receptor antagonism, can indirectly impact the phosphorylation status of proteins that regulate NaBC1, thus enhancing its activity. Collectively, these activators, through their targeted biochemical actions, facilitate an increase in NaBC1 activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is an adenylyl cyclase activator, leading to increased levels of cAMP in cells. Elevated cAMP may indirectly enhance NaBC1 function by activating PKA, which could phosphorylate proteins that modulate the activity of NaBC1. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin Gallate is a polyphenol found in green tea with multiple cellular effects. It has been known to inhibit certain types of cellular kinases, which may relieve inhibitory phosphorylation on transporters related to NaBC1, potentially increasing NaBC1 activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, enzymes that degrade cAMP and cGMP. By preventing cAMP degradation, IBMX can indirectly increase NaBC1 activity through cAMP-dependent pathways. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin is an active component of chili peppers that binds to TRPV1 receptors, leading to an influx of calcium ions. This increase in intracellular calcium may indirectly stimulate NaBC1 activity by activating calcium-dependent protein kinases that modulate NaBC1. | ||||||
Docosa-4Z,7Z,10Z,13Z,16Z,19Z-hexaenoic Acid (22:6, n-3) | 6217-54-5 | sc-200768 sc-200768A sc-200768B sc-200768C sc-200768D | 100 mg 1 g 10 g 50 g 100 g | $92.00 $206.00 $1744.00 $7864.00 $16330.00 | 11 | |
DHA, an omega-3 fatty acid, can incorporate into cell membranes, altering their fluidity and potentially affecting the activity of membrane proteins including NaBC1. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin is a bioactive compound in turmeric with anti-inflammatory properties. It may modulate the activity of various signaling pathways and could indirectly enhance NaBC1 activity by affecting the cellular localization or protein-protein interactions. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc is a trace element that can act as a cofactor for various enzymes and modulate the activity of several ion channels and transporters, potentially including NaBC1. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Verapamil is a calcium channel blocker that by reducing calcium influx, might alter the phosphorylation status of proteins that regulate NaBC1, indirectly enhancing its activity. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine is a known phosphodiesterase inhibitor as well as an adenosine receptor antagonist, leading to increased cAMP levels in cells. This can indirectly influence NaBC1 activity through cAMP-mediated signaling pathways. | ||||||