Myotilin Inhibitors
Myotilin inhibitors belong to a distinctive chemical class renowned for their targeted modulation of myotilin, a protein predominantly expressed in skeletal and cardiac muscle tissues. Myotilin, a sarcomeric Z-disc protein, plays a crucial role in maintaining the structural integrity of muscle fibers and contributes to the organization of sarcomeres, the fundamental contractile units of muscles. The development of myotilin inhibitors stems from a deeper understanding of the intricate molecular mechanisms governing muscle function and the quest to identify small molecules that can selectively modulate specific protein interactions.
Myotilin inhibitors are designed to interact with the myotilin protein, specifically targeting key binding sites or regulatory regions involved in its functional activities. The goal is to modulate myotilin's interactions with other cellular components, potentially altering its role in the maintenance of muscle structure and function. By interfering with the normal functioning of myotilin, these inhibitors may offer insights into the underlying biology of muscle tissue and provide a platform for investigating the consequences of targeted modulation.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Binds to the barbed ends of actin filaments, leading to disruption of actin polymerization which is essential for myotilin function. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Sequesters actin monomers and prevents their polymerization, affecting the actin cytoskeleton and thus potentially altering myotilin's role. | ||||||
Swinholide A, Theonella swinhoei | 95927-67-6 | sc-205914 | 10 µg | $135.00 | ||
Acts as an actin filament severing agent, which can indirectly affect myotilin's structural role in muscle cells. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Stabilizes actin filaments and can thereby affect the dynamics necessary for myotilin's function. | ||||||
Phalloidin | 17466-45-4 | sc-202763 | 1 mg | $234.00 | 33 | |
Binds and stabilizes filaments, affecting actin dynamics and potentially the function of myotilin within the cytoskeleton. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
Inhibits myosin light chain kinase, thereby affecting muscle contraction and potentially the stability of myotilin-linked structures. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Inhibits ROCK (Rho-associated protein kinase), which can alter actin organization and potentially affect myotilin-associated pathways. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $183.00 $313.00 $464.00 $942.00 $1723.00 | 7 | |
Inhibits myosin II, and thus muscle fiber function, which can indirectly affect the structural integrity where myotilin is involved. | ||||||
SMIFH2 | 340316-62-3 | sc-507273 | 5 mg | $140.00 | ||
Disrupts formin-mediated actin nucleation, potentially impacting actin structures linked with myotilin. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $321.00 $1040.00 | 5 | |
Inhibits the Arp2/3 complex, which can disrupt actin filament branching, a process that could influence myotilin's function. | ||||||