myopalladin Inhibitors
Myopalladin inhibitors are a class of chemical compounds that specifically target myopalladin, a structural protein primarily found in muscle cells, where it plays a crucial role in maintaining the integrity and function of the sarcomere, the fundamental unit of muscle contraction. Myopalladin interacts with several key proteins within the sarcomere, including actin and titin, to ensure proper alignment and mechanical stability during muscle contraction and relaxation. Additionally, myopalladin acts as a scaffold for signaling molecules, helping to regulate muscle development and response to mechanical stress. Inhibitors of myopalladin disrupt its interactions with these proteins, leading to alterations in sarcomere structure and muscle function.
The mechanism of action for myopalladin inhibitors generally involves blocking the binding sites where myopalladin interacts with other sarcomeric proteins such as actin or titin. By disrupting these interactions, the inhibitors prevent myopalladin from fulfilling its role in maintaining sarcomere integrity, which can lead to structural instability in muscle cells and improper force transmission during muscle contraction. Myopalladin inhibitors are valuable tools for studying the molecular dynamics of muscle function and the role of sarcomeric proteins in maintaining muscle architecture. Researchers utilize these inhibitors to investigate how disruptions in protein-protein interactions within the sarcomere impact muscle physiology, providing deeper insights into the complex processes governing muscle contraction, stability, and cellular signaling in muscle tissues.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $183.00 $313.00 $464.00 $942.00 $1723.00 | 7 | |
A myosin II inhibitor that prevents myosin from binding to actin, thus affecting muscle contraction. By disrupting the actomyosin complex, it may indirectly affect myopalladin's structural role in muscle integrity. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
An inhibitor of myosin light chain kinase (MLCK), which is involved in muscle contraction. By inhibiting MLCK, ML-7 could indirectly affect the structural organization of muscle cells, potentially impacting myopalladin's function. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
A ROCK inhibitor that affects actin cytoskeleton organization. By altering actin dynamics, Y-27632 could indirectly influence the structural context in which myopalladin operates, affecting its role in muscle cells. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
An actin polymerization inhibitor, leading to the disruption of actin filaments. This disruption could indirectly affect myopalladin's interaction with actin and its role in muscle cell structure. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
By binding to tubulin, colchicine inhibits microtubule polymerization, affecting cell division and cytoskeletal organization. This could indirectly impact the structural integrity of muscle cells where myopalladin functions. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $49.00 $124.00 $441.00 $828.00 | 4 | |
A specific inhibitor of the N-WASP, which is a regulator of actin polymerization. By inhibiting N-WASP, Wiskostatin may indirectly affect the organization of actin, potentially impacting myopalladin's function. | ||||||
SMIFH2 | 340316-62-3 | sc-507273 | 5 mg | $140.00 | ||
An inhibitor of formin-mediated actin assembly, thereby affecting actin filament formation. This action could indirectly influence myopalladin's function in maintaining muscle cell structure. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
A cyclodepsipeptide that stabilizes actin filaments and promotes their polymerization. By altering actin dynamics, it could indirectly affect the role of myopalladin in muscle cells. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Binds to actin monomers, preventing their polymerization. This could indirectly disrupt myopalladin's ability to maintain structural integrity in muscle cells. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $130.00 $583.00 $4172.00 $20506.00 | 20 | |
A steroidal lactone that disrupts vimentin filaments, another component of the cytoskeleton. Though not directly affecting actin, its role in altering cytoskeletal dynamics could indirectly impact myopalladin's function. | ||||||