MuRF3 Activators
Chemical activators of MuRF3 play a significant role in the regulation of muscle function and protein turnover. Phosphocreatine, by donating a phosphate group to ADP to regenerate ATP, supports energy-dependent muscle processes in which MuRF3 is inherently involved, thereby promoting its activity in muscle protein regulation. Similarly, epicatechin enhances nitric oxide production, which is crucial for blood flow and muscle contractility. This biochemical cascade can activate MuRF3 as the protein responds to increased mechanical muscle stress. Forskolin, through the elevation of cAMP, activates PKA, which can phosphorylate substrates involved in muscle dynamics, potentially engaging MuRF3 in its role to modulate muscle protein degradation. Caffeine, by increasing calcium release, can also heighten muscle contraction, thus indirectly activating MuRF3 in response to elevated mechanical load. AICAR, which activates AMPK, influences MuRF3 by engaging it in energy regulation within muscle cells, while resveratrol's activation of SIRT1 can lead to deacetylation processes that indirectly trigger MuRF3 activity.
Curcumin, by affecting NF-κB signaling, can activate MuRF3, promoting its role in muscle protein degradation under stress. Sildenafil's enhancement of nitric oxide signaling can activate MuRF3 through improved muscle function and adaptation to mechanical stress. Capsaicin interacts with sensory neurons affecting muscle metabolism and could activate MuRF3 during muscle metabolic transitions. Allicin influences stress responses and cellular metabolism, thereby activating MuRF3 in muscle cells under metabolic stress. Finally, zinc, essential for enzyme function and protein handling, is vital for maintaining muscle tissue integrity and can activate MuRF3 function in the maintenance and repair of muscle proteins.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)Epicatechin | 490-46-0 | sc-205672 sc-205672A | 1 mg 5 mg | $51.00 $138.00 | ||
Epicatechin can enhance nitric oxide production, which improves blood flow and muscle contraction. Improved muscle contraction increases mechanical stress, which can activate MuRF3 to modulate sarcomeric protein turnover in response to muscle activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing cAMP levels, which in turn activate PKA. PKA can phosphorylate target proteins involved in muscle function, potentially enhancing MuRF3 activity related to muscle protein degradation. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine increases calcium release within muscle cells, thereby enhancing muscle contraction. Through this mechanism, caffeine can indirectly activate MuRF3 by increasing the mechanical load and stress on muscle fibers, which MuRF3 is known to respond to. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR activates AMPK, which is involved in cellular energy homeostasis. Activation of AMPK can lead to the functional activation of MuRF3 in the context of regulating energy-dependent processes within muscle cells. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol can activate SIRT1, which regulates protein deacetylation, including factors involved in muscle function and metabolism. This activation can indirectly lead to the functional activation of MuRF3, which is involved in muscle protein turnover. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin has been shown to affect NF-κB signaling, which is involved in inflammatory responses and muscle wasting. By modulating this pathway, curcumin can indirectly activate MuRF3, promoting its role in muscle protein degradation under stress conditions. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin interacts with sensory neurons and can influence muscle fiber type transition and metabolism. This interaction may activate MuRF3 through altered muscle metabolic demands and adaptation. | ||||||
Allicin | 539-86-6 | sc-202449 sc-202449A | 1 mg 5 mg | $489.00 $1557.00 | 7 | |
Allicin has been shown to influence cellular metabolism and stress responses. These effects can lead to the activation of MuRF3 in muscle cells, as it is involved in the regulation of proteins during metabolic stress. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc is a co-factor for many enzymes and is involved in protein synthesis and degradation. Adequate zinc levels are necessary for muscle health and can activate MuRF3 function in the maintenance of muscle tissue integrity. | ||||||