MURC Inhibitors
MURC inhibitors, short for Muscle-Related Coiled-Coil Protein Inhibitors, represent a class of chemical compounds that are designed to target and modulate the activity of the Muscle-Related Coiled-Coil (MURC) protein. The MURC protein, also known as Cavin-4 or SRBC, is a cytosolic and membrane-associated protein that plays a crucial role in cellular processes related to muscle physiology and lipid metabolism. MURC is primarily expressed in cardiac and skeletal muscle tissues, and it has been implicated in various cellular functions, including sarcomere organization, signal transduction, and regulation of lipid homeostasis. MURC inhibitors are synthetic molecules that have been developed to specifically interact with MURC, either by blocking its activity or altering its cellular localization.
MURC inhibitors can vary widely in structure, as they are designed to interact with specific binding sites or functional domains within the MURC protein. These inhibitors may act by disrupting protein-protein interactions, interfering with post-translational modifications, or affecting the stability of the MURC protein. Through their targeted interactions with MURC, these inhibitors can potentially modulate the biological functions associated with this protein. Further research is ongoing to elucidate the precise mechanisms and potential applications of MURC inhibitors, particularly in the context of muscle-related disorders and lipid metabolism regulation.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Binds to cyclophilin, inhibiting the phosphatase activity of calcineurin, thus reduces NFAT activation which is a pathway MURC is implicated in. | ||||||
FK-506 | 104987-11-3 | sc-24649 sc-24649A | 5 mg 10 mg | $78.00 $151.00 | 9 | |
Forms a complex with FKBP12, inhibiting calcineurin and thus diminishing NFAT activity, indirectly affecting MURC-related pathways. | ||||||
NFAT Inhibitor | 249537-73-3 | sc-507480 | 1 mg | $620.00 | ||
Specifically inhibits NFAT-calcineurin interactions without affecting other calcineurin functions, impacting pathways involving MURC. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Inhibits NFAT activation and may affect the transcription of genes regulated by MURC. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
A polyphenol that can inhibit NFAT activity and may thus indirectly influence MURC's function in hypertrophic signaling. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
Inhibits MEK, which is upstream of pathways MURC is suspected to play a role in, can therefore alter MURC's activity indirectly. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
Inhibits p38 MAPK, potentially affecting MURC's role in stress response pathways in muscle cells. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
Inhibits JNK, which can modulate signaling pathways involving MURC, possibly affecting its function. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Inhibits PI3K, upstream of several signaling cascades involving MURC, can affect the protein's activity indirectly. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
Another PI3K inhibitor that can alter signaling pathways where MURC may be implicated. | ||||||