Mucin 3B Activators
Mucin 3B Activators comprise a diverse set of chemical entities that augment the functional activity of Mucin 3B through distinct signaling pathways and molecular mechanisms. Compounds such as Forskolin elevate intracellular cAMP levels, thereby activating PKA, which is known to phosphorylate target proteins that are integral to the mucin secretion pathway, thus amplifying the activity of Mucin 3B. Similarly, Curcumin modulates the NF-κB pathway, which plays a pivotal role in mucin gene regulation, enhancing Mucin 3B's role in the mucosal barrier. Retinoic Acid, on the other hand, acts on cellular differentiation pathways to upregulate Mucin 3B expression, while Quercetin's modulation of the PI3K/Akt pathway likewise leads to transcriptional changes that increase Mucin 3B activity.
The activity of Mucin 3B is further influenced by compounds like Sulforaphane and Epigallocatechin Gallate (EGCG), which activate the Nrf2 pathway and inhibit certain kinases, respectively-each altering signaling cascades that culminate in enhanced Mucin 3B expression. Capsaicin's interaction with TRPV1 and Butyrate's role as a histone deacetylase inhibitor both lead to increased Mucin 3B activity via calcium-dependent signaling and chromatin remodeling. Lithium Chloride and Sodium Butyrate promote gene expression through Wnt signaling and histone modification, respectively. Resveratrol's action on sirtuins and AMPK pathways and N-Acetylcysteine's maintenance of cellular redox balance also contribute to creating an optimal environment for Mucin 3B's expression and function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, which increases intracellular cAMP levels. Elevated cAMP can enhance Mucin 3B signaling by promoting PKA activation, which can phosphorylate proteins involved in the mucin secretion pathway, thereby enhancing the functional activity of Mucin 3B. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin modulates cell signaling pathways, including the NF-κB pathway, which is implicated in the regulation of mucin gene expression. By inhibiting NF-κB activation, Curcumin can enhance Mucin 3B expression and function as part of the mucosal barrier. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid influences the differentiation of epithelial cells and modulates the expression of genes involved in mucin production. By acting on cellular differentiation pathways, Retinoic Acid can lead to the upregulation of Mucin 3B expression. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin, a flavonoid, has been shown to modulate the PI3K/Akt pathway, which can lead to the upregulation of Mucin 3B by influencing transcription factors involved in mucin gene expression. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane activates the Nrf2 pathway, which is known to regulate the expression of detoxification and antioxidant proteins. This activation can also enhance the functional activity of Mucin 3B, as Nrf2 can influence mucin gene expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG inhibits certain kinases, potentially altering the signaling cascades that lead to mucin expression. By inhibiting competitive signaling pathways, EGCG can enhance the functional activity of Mucin 3B. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin binds to the transient receptor potential vanilloid 1 (TRPV1), which can lead to increased intracellular calcium levels and activate calcium-dependent signaling pathways. These pathways can enhance the secretion and functional activity of Mucin 3B. | ||||||
Butyric acid | 107-92-6 | sc-214640 sc-214640A | 1 kg 10 kg | $63.00 $174.00 | ||
Butyrate, a short-chain fatty acid, acts as a histone deacetylase inhibitor, which can lead to the hyperacetylation of histones and the upregulation of gene expression. This process can enhance Mucin 3B expression by modifying chromatin structure around the MUC3B gene. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride inhibits GSK-3β, which can lead to the stabilization of β-catenin and activation of Wnt signaling. Activation of this pathway can lead to the enhanced expression of Mucin 3B. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium Butyrate, similar to Butyrate, acts as a histone deacetylase inhibitor, leading to enhanced acetylation of histones and promoting gene expression, including the upregulation of Mucin 3B expression. | ||||||