MS4A6A Activators
MS4A6A operate through a common pathway involving the elevation of intracellular cyclic adenosine monophosphate (cAMP) levels and the subsequent activation of protein kinase A (PKA). Forskolin, a direct activator of adenylyl cyclase, increases cAMP levels, thereby enhancing PKA activity. PKA then phosphorylates MS4A6A, leading to its functional activation. Similarly, IBMX, by inhibiting phosphodiesterases, prevents the degradation of cAMP, which also results in the activation of PKA and the phosphorylation of MS4A6A. Prostaglandin E2 (PGE2) works through its own G-protein coupled receptors to raise cAMP and activate PKA, which in turn activates MS4A6A. Adrenergic agonists like isoproterenol, epinephrine, and norepinephrine bind to their respective receptors, leading to adenylyl cyclase activation, cAMP accumulation, PKA activation, and subsequent MS4A6A phosphorylation.
Histamine, upon binding to H2 receptors, and dopamine, through D1 receptors, both lead to increased cAMP levels and PKA activation, culminating in the phosphorylation of MS4A6A. Adenosine similarly engages with A2 receptors to elevate cAMP and activate PKA, which phosphorylates MS4A6A. Glucagon, another activator, binds to its receptor, triggering a cascade that includes adenylyl cyclase activation, cAMP production, PKA activation, and MS4A6A phosphorylation. Beta2-adrenergic agonists, such as terbutaline, also increase cAMP by stimulating adenylyl cyclase, leading to PKA activation and MS4A6A phosphorylation. Finally, rolipram, by selectively inhibiting phosphodiesterase 4, increases cAMP levels, thus enhancing PKA activity and fostering the phosphorylation and activation of MS4A6A. Each chemical, through its unique interaction with cellular components, converges on the pathway that leads to MS4A6A activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly activates adenylyl cyclase, increasing cAMP levels. Elevated cAMP can lead to the activation of protein kinase A (PKA), which may phosphorylate MS4A6A, leading to its functional activation. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-specific inhibitor of phosphodiesterases, which prevents the breakdown of cAMP and cGMP. This results in increased PKA activity, potentially leading to the phosphorylation and activation of MS4A6A. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
Prostaglandin E2 binds to its G-protein coupled receptors, leading to an increase in intracellular cAMP, which can enhance PKA activity and potentially lead to the phosphorylation and functional activation of MS4A6A. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that increases intracellular levels of cAMP through the activation of adenylyl cyclase. This cAMP elevation can activate PKA and subsequently phosphorylate and activate MS4A6A. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine binds to adrenergic receptors, particularly the beta subtype, which activates adenylyl cyclase and increases cAMP levels. The cAMP activates PKA, which could lead to the activation of MS4A6A through phosphorylation. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $92.00 $277.00 $969.00 | 7 | |
Histamine can bind to H2 receptors, a Gs protein-coupled receptor, leading to an increase in cAMP levels. The subsequent activation of PKA might phosphorylate and activate MS4A6A. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine, through its D1 receptors (D1-like family), can activate adenylyl cyclase, raising cAMP levels and activating PKA, which in turn may phosphorylate and activate MS4A6A. | ||||||
L-Noradrenaline | 51-41-2 | sc-357366 sc-357366A | 1 g 5 g | $320.00 $475.00 | 3 | |
Norepinephrine acts on beta-adrenergic receptors to increase intracellular cAMP levels, activating PKA, which could phosphorylate and activate MS4A6A. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $33.00 $47.00 $294.00 $561.00 $1020.00 $2550.00 $4590.00 | 1 | |
Adenosine interacts with A2 receptors, which are coupled to Gs proteins that activate adenylyl cyclase, increasing cAMP and activating PKA. PKA activation could lead to phosphorylation and activation of MS4A6A. | ||||||
Terbutaline Hemisulfate | 23031-32-5 | sc-204911 sc-204911A | 1 g 5 g | $90.00 $371.00 | 2 | |
Terbutaline is a beta2-adrenergic agonist that increases cAMP levels by activating adenylyl cyclase, which leads to PKA activation. PKA could potentially phosphorylate and activate MS4A6A. | ||||||