MRP-L46 Activators
MRP-L46 Activators encompass a variety of chemical compounds that facilitate the enhancement of MRP-L46 activity within mitochondrial biogenesis and function. Compounds such as Forskolin and PQQ engage cyclic AMP signaling and CREB/PGC-1α axis, respectively, leading to the promotion of mitochondrial biogenesis-a process where MRP-L46 plays a crucial role. Through this induction, these activators aid in increasing the demand for and activity of the mitochondrial ribosomal protein MRP-L46, as more ribosomes are required to translate mitochondrial proteins. Similarly, Resveratrol and SRT1720, by activating SIRT1, and Pioglitazone, as a PPAR-gamma agonist, stimulate mitochondrial function and biogenesis. This upregulation of mitochondrial quality control and protein synthesis pathways can be expected to enhance the functional role of MRP-L46 in mitochondrial protein translation, contributing to the overall health and efficiency of the mitochondria.
Furthermore, metabolic regulators such as AICAR, NMN, and Metformin act on pathways like AMPK signaling to promote mitochondrial biogenesis, which in turn would necessitate an increase in the activity of MRP-L46 to meet the heightened requirements for mitochondrial protein synthesis. Bezafibrate enhances fatty acid oxidation and mitochondrial respiration, processes that are intricately linked to mitochondrial biogenesis, where MRP-L46 is essential. Rapamycin and Urolithin A trigger autophagy and mitophagy, respectively, leading to the renewal of mitochondrial components including ribosomal proteins such as MRP-L46, therefore potentially upregulating its activity indirectly. Collectively, these activators demonstrate a multifaceted approach to enhancing MRP-L46 activity, by influencing pathways that converge on the need for efficient mitochondrial protein synthesis machinery, where MRP-L46 is a pivotal component.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, leading to increased levels of cAMP, which in turn can enhance the activity of MRP-L46 by promoting mitochondrial biogenesis through the cAMP/PKA/CREB pathway. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates SIRT1, which is known to stimulate mitochondrial function and biogenesis. Enhanced SIRT1 activity may lead to the increased activity of MRP-L46 by improving mitochondrial protein quality control. | ||||||
SRT1720 | 1001645-58-4 | sc-364624 sc-364624A | 5 mg 10 mg | $193.00 $357.00 | 13 | |
SRT1720 is a SIRT1 activator which can indirectly enhance MRP-L46 activity by improving mitochondrial efficiency and biogenesis, as SIRT1 influences the deacetylation and activity of PGC-1α, a regulator of mitochondrial genes. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $54.00 $123.00 | 13 | |
Pioglitazone, a PPAR-gamma agonist, can lead to the transcriptional activation of genes involved in mitochondrial function, potentially upregulating the activity of MRP-L46 as part of the mitochondrial protein complex. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR activates AMPK, which can promote mitochondrial biogenesis and, in turn, enhance MRP-L46 activity by increasing the demand for mitochondrial translation machinery. | ||||||
β-Nicotinamide mononucleotide | 1094-61-7 | sc-212376 sc-212376A sc-212376B sc-212376C sc-212376D | 25 mg 100 mg 1 g 2 g 5 g | $92.00 $269.00 $337.00 $510.00 $969.00 | 4 | |
NMN increases NAD+ levels, which in turn activates SIRT1, leading to enhanced mitochondrial function and potentially increasing the activity of MRP-L46 through improved mitochondrial protein homeostasis. | ||||||
Bezafibrate | 41859-67-0 | sc-204650B sc-204650 sc-204650A sc-204650C | 500 mg 1 g 5 g 10 g | $30.00 $45.00 $120.00 $200.00 | 5 | |
Bezafibrate, as a PPAR pan-agonist, can stimulate the expression of genes involved in fatty acid oxidation and mitochondrial respiration, possibly enhancing the activity of MRP-L46 within the mitochondria. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $77.00 | 2 | |
Metformin activates AMPK and can enhance mitochondrial biogenesis and function, which may indirectly increase MRP-L46 activity within the mitochondrial translation system. | ||||||
Pyrroloquinoline quinone | 72909-34-3 | sc-210178 | 1 mg | $238.00 | ||
PQQ can stimulate mitochondrial biogenesis through activation of CREB and PGC-1α, potentially enhancing the functional activity of MRP-L46 in mitochondrial protein synthesis. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, which can induce a shift toward increased autophagy and mitochondrial renewal, thereby potentially increasing MRP-L46 activity through the turnover of mitochondrial components. | ||||||