Moesin Activators
Moesin activators encompass a diverse array of chemicals that intricately modulate the activity of Moesin, a member of the ERM (Ezrin, Radixin, Moesin) protein family crucial for linking the actin cytoskeleton to the plasma membrane. While there are no direct activators identified, various compounds exert their effects on Moesin through indirect mechanisms, emphasizing the interconnected signaling pathways governing cellular morphology and motility. Among the highlighted compounds, Calyculin A emerges as a potent indirect activator by inhibiting protein phosphatases 1 and 2A, leading to increased phosphorylation and activation of Moesin. The indirect activation of Moesin by Jasplakinolide emphasizes the dependence on F-actin dynamics, as it stabilizes actin filaments, promoting Moesin interaction. Y-27632, a selective Rho kinase (ROCK) inhibitor, indirectly activates Moesin by disrupting the RhoA/ROCK pathway, demonstrating the interplay between RhoA signaling and Moesin activity in cellular processes such as adhesion and migration. Additionally, small molecules like H-89 and ML-7 impact Moesin indirectly by influencing the cAMP/PKA pathway and myosin light chain kinase (MLCK), respectively.
Compounds like NSC23766 and CK-666 indirectly activate Moesin by influencing the RhoA/ROCK pathway and actin polymerization, respectively. The crosstalk between Rac1, RhoA/ROCK, and Moesin is highlighted, illustrating the complexity of signaling networks regulating Moesin activation. A23187, a calcium ionophore, and BAPTA-AM, a calcium chelator, indirectly modulate Moesin by affecting calcium-dependent signaling pathways, further emphasizing the pivotal role of calcium in Moesin activation. Furthermore, MLN4924, a small molecule inhibitor of NEDD8-activating enzyme, indirectly activates Moesin by impacting the NEDDylation pathway, connecting the regulation of Moesin expression to ubiquitin-like protein modification.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $160.00 $750.00 | 59 | |
Calyculin A, a potent protein phosphatase inhibitor, indirectly activates Moesin by affecting the actin cytoskeleton. It inhibits protein phosphatase 1 and 2A, leading to increased phosphorylation of Moesin and its activation. The indirect modulation of Moesin by Calyculin A underscores the importance of protein phosphatases in regulating the activity of Moesin and its role in cytoskeletal dynamics. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $180.00 $299.00 | 59 | |
Jasplakinolide, a natural product, indirectly activates Moesin by stabilizing F-actin. By promoting actin polymerization, Jasplakinolide enhances the interaction between Moesin and actin filaments, leading to increased Moesin activation. This indirect modulation highlights the connection between the actin cytoskeleton and Moesin activity, emphasizing the role of F-actin dynamics in regulating Moesin function. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632, a selective Rho kinase (ROCK) inhibitor, indirectly activates Moesin by disrupting the RhoA/ROCK pathway. Inhibition of ROCK leads to decreased phosphorylation and activation of Moesin. The indirect modulation of Moesin by Y-27632 highlights the significance of the RhoA/ROCK pathway in regulating Moesin activity and the actin cytoskeleton. | ||||||
ML-9 | 105637-50-1 | sc-200519 sc-200519A sc-200519B sc-200519C | 10 mg 50 mg 100 mg 250 mg | $110.00 $440.00 $660.00 $1200.00 | 2 | |
ML-7, a myosin light chain kinase (MLCK) inhibitor, indirectly activates Moesin by influencing actomyosin contractility. Inhibition of MLCK by ML-7 reduces myosin light chain (MLC) phosphorylation, leading to increased Moesin activation. The indirect modulation of Moesin by ML-7 emphasizes the crosstalk between MLCK, MLC phosphorylation, and Moesin activity in the regulation of cell morphology and motility. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $179.00 $307.00 $455.00 $924.00 $1689.00 | 7 | |
Blebbistatin, a selective myosin II ATPase inhibitor, indirectly activates Moesin by disrupting actomyosin contractility. Inhibition of myosin II by Blebbistatin reduces actin-myosin interactions, leading to increased Moesin activation. The indirect modulation of Moesin by Blebbistatin highlights the interplay between myosin II activity and Moesin function, emphasizing their coordinated role in cytoskeletal dynamics. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
Cytochalasin D, a disruptor of actin polymerization, indirectly activates Moesin by influencing actin dynamics. By preventing actin filament elongation, Cytochalasin D enhances the interaction between Moesin and actin, leading to increased Moesin activation. The indirect modulation of Moesin by Cytochalasin D highlights the dependence of Moesin activity on the integrity and dynamics of the actin cytoskeleton. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187, a calcium ionophore, indirectly activates Moesin by affecting calcium-dependent signaling pathways. Increased intracellular calcium levels induced by A23187 lead to the activation of calmodulin-dependent kinases, which phosphorylate and activate Moesin. The indirect modulation of Moesin by A23187 underscores the role of calcium signaling in regulating Moesin activity and its impact on cellular processes such as adhesion and migration. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $280.00 | 1 | |
MLN4924, a small molecule inhibitor of NEDD8-activating enzyme (NAE), indirectly activates Moesin by impacting the NEDDylation pathway. Inhibition of NAE by MLN4924 stabilizes the tumor suppressor protein p53, which activates Moesin transcription. The indirect modulation of Moesin by MLN4924 highlights the connection between NEDDylation, p53, and Moesin expression, illustrating the intricate regulatory network influencing Moesin activation and cellular responses. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $449.00 | 61 | |
BAPTA-AM, a calcium chelator, indirectly activates Moesin by sequestering intracellular calcium. Chelation of calcium by BAPTA-AM reduces calcium-dependent signaling, impacting calmodulin-dependent kinases that regulate Moesin activity. The indirect modulation of Moesin by BAPTA-AM emphasizes the critical role of calcium signaling in regulating Moesin activation and its involvement in cellular processes such as cell adhesion and migration. | ||||||