Mlp2 Inhibitors
Chemical inhibitors of Mlp2 function through various mechanisms to disrupt the microtubule network within the cell, which is essential for Mlp2's role in cellular processes. Paclitaxel and related compounds such as Peloruside A and Laulimalide stabilize microtubules, preventing their disassembly and thus inhibiting Mlp2 by locking the microtubule network in a rigid state. This stabilization impedes the dynamic rearrangement of the cytoskeleton required for Mlp2 to carry out its functions in maintaining nuclear architecture and positioning. On the other hand, Vinblastine and Vincristine bind to tubulin, inhibiting microtubule formation and leading to the collapse of the microtubule network. This collapse disrupts Mlp2's role in cellular organization, as the protein relies on an intact microtubule scaffold to perform its structural and transport-related functions.
Other inhibitors such as Colchicine and Combretastatin A-4 bind to tubulin at the colchicine site, impeding microtubule polymerization and thus inhibiting the function of Mlp2 by removing the tracks along which it operates. Nocodazole also disrupts microtubule polymerization, inducing depolymerization and effectively disassembling the microtubule network that Mlp2 depends on. Cryptophycin 1, with its potent microtubule destabilizing action, similarly inhibits Mlp2 by dismantling the cytoskeletal infrastructure. Compounds like Podophyllotoxin and Griseofulvin interfere with microtubule assembly and function, respectively. Podophyllotoxin binds to tubulin and prevents microtubule assembly, while Griseofulvin disrupts microtubule function by interacting with polymerized microtubules. Both actions result in the inhibition of Mlp2's ability to maintain cellular structure. Eribulin, by inhibiting the growth phase of microtubule polymerization, compromises Mlp2's role in the cellular architecture and transport processes, further illustrating the various ways in which chemical inhibitors can impede Mlp2 function by targeting the essential microtubule network upon which it relies.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Paclitaxel stabilizes microtubules and thereby inhibits their disassembly, which is essential for mitotic and interphase cellular functions. Mlp2, as a protein linked to the cytoskeleton, would be inhibited in function due to the disruption of microtubule dynamics, as it can no longer perform its role in the structural organization and intracellular transport. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Colchicine binds to tubulin, preventing its polymerization into microtubules, leading to the disruption of microtubule function. By destabilizing microtubules, colchicine would inhibit the function of Mlp2, which is dependent on an intact cytoskeleton for its role in maintaining nuclear architecture and positioning. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $100.00 $230.00 $450.00 $1715.00 $2900.00 | 4 | |
Vinblastine binds to tubulin and inhibits microtubule formation, which affects cellular functions that rely on microtubule integrity. Mlp2's function would be inhibited as it relies on the microtubule network for molecular transport and cellular structure maintenance. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole is a synthetic compound that disrupts microtubule polymerization and induces microtubule depolymerization, impeding cellular processes relying on microtubules. The function of Mlp2, which is related to microtubule-based processes, would be inhibited due to the disruption of the cytoskeletal framework it depends on. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $82.00 | 1 | |
Podophyllotoxin is a toxin that binds to tubulin and inhibits the assembly of microtubules. As Mlp2 functions are associated with the microtubule network, its ability to maintain cellular structure would be inhibited by the disruption of microtubule dynamics. | ||||||
Eribulin | 253128-41-5 | sc-507547 | 5 mg | $865.00 | ||
Eribulin is a microtubule dynamics inhibitor that works by inhibiting the growth phase of microtubule polymerization. By preventing proper microtubule formation, Mlp2's role in the cellular architecture and transport processes would be inhibited. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $83.00 $216.00 $586.00 | 4 | |
Griseofulvin disrupts microtubule function by interacting with polymerized microtubules, inhibiting mitotic spindle formation. Mlp2, which requires a functional microtubule network, would have its role in cell division and structural integrity inhibited. | ||||||
Laulimalide | 115268-43-4 | sc-507261 | 100 µg | $200.00 | ||
Laulimalide is another microtubule-stabilizing agent that would inhibit Mlp2 function by similar mechanisms as Paclitaxel and Peloruside A, disrupting the dynamic instability of microtubules essential for Mlp2's cellular roles. | ||||||