Mitofilin inhibitors are a class of chemical compounds that specifically target and inhibit the function of mitofilin, a key protein located in the inner mitochondrial membrane. Mitofilin is an essential component of the mitochondrial inner membrane organizing system (MINOS), also known as the mitochondrial contact site and cristae organizing system (MICOS). This protein plays a pivotal role in maintaining the structural integrity of mitochondrial cristae, which are the folds within the inner membrane that increase surface area for essential metabolic processes, such as ATP production. Mitofilin's role in the regulation of cristae morphology is crucial for maintaining proper mitochondrial function and energy production, and its inhibition can lead to disruptions in these processes.
Chemically, mitofilin inhibitors are designed to interfere with the protein's ability to form or stabilize the MICOS complex. These inhibitors may bind to mitofilin directly, preventing its interaction with other components of the complex, or they may cause conformational changes that alter its structural role within the inner mitochondrial membrane. Structure-activity relationship (SAR) studies are typically employed to refine the specificity of these inhibitors, ensuring that they selectively target mitofilin without affecting other mitochondrial proteins. By inhibiting mitofilin, researchers are able to investigate the broader effects on mitochondrial dynamics, cristae organization, and overall cellular energy homeostasis. These inhibitors provide valuable insights into the molecular mechanisms governing mitochondrial architecture and function, helping to elucidate the role of mitofilin in maintaining the intricate balance of cellular metabolism.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
It can inhibit the mitochondrial permeability transition pore (MPTP), a complex believed to involve Mitofilin. This action can indirectly affect Mitofilin function. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $77.00 | 2 | |
This compound can interfere with the mitochondrial electron transport chain, which can indirectly influence Mitofilin function due to its role in mitochondrial structure and function. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $254.00 | 41 | |
It inhibits mitochondrial complex I, potentially influencing the overall mitochondrial function and thereby Mitofilin. | ||||||
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $54.00 $62.00 $1642.00 $4600.00 | 51 | |
This compound inhibits mitochondrial complex III, indirectly impacting Mitofilin due to its role in maintaining mitochondrial integrity. | ||||||
FCCP | 370-86-5 | sc-203578 sc-203578A | 10 mg 50 mg | $92.00 $348.00 | 46 | |
FCCP uncouples oxidative phosphorylation in mitochondria, which can indirectly affect Mitofilin function. | ||||||
Oligomycin | 1404-19-9 | sc-203342 sc-203342C | 10 mg 1 g | $146.00 $12250.00 | 18 | |
It inhibits mitochondrial ATP synthase, potentially impacting mitochondrial function and thereby Mitofilin. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR (mechanistic target of rapamycin), a key regulator of cell growth and proliferation that influences mitochondrial function. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $65.00 $210.00 | 26 | |
This glucose analogue inhibits glycolysis and shifts cellular metabolism towards mitochondrial respiration, which can indirectly influence Mitofilin. | ||||||
Carbonyl Cyanide m-Chlorophenylhydrazone | 555-60-2 | sc-202984A sc-202984 sc-202984B | 100 mg 250 mg 500 mg | $75.00 $150.00 $235.00 | 8 | |
CCCP is an uncoupling agent that disrupts mitochondrial membrane potential, indirectly influencing Mitofilin. | ||||||
Valinomycin | 2001-95-8 | sc-200991 | 25 mg | $163.00 | 3 | |
It is a potassium ionophore and can disrupt mitochondrial membrane potential, thereby having an indirect effect on Mitofilin. | ||||||