MELK Activators
MELK activators, in the broader sense described here, encompass a range of chemicals that indirectly influence the activity of Maternal Embryonic Leucine Zipper Kinase. These chemicals act through diverse mechanisms, impacting various signaling pathways and cellular processes that can intersect with or modulate the functional role of MELK.
The chemicals listed, such as forskolin, EGF, and IGF-1, do not directly activate MELK but instead influence cellular processes that could potentially modify MELK activity. Forskolin, for example, raises intracellular cAMP levels, affecting multiple kinases and signaling cascades. Similarly, growth factors like EGF and IGF-1 trigger receptor tyrosine kinase pathways, which are known to play roles in cell cycle regulation and apoptosis, processes where MELK is also involved. Additionally, other compounds like phorbol esters (PMA), hormones (estrogen, testosterone), and vitamins (retinoic acid, vitamin D3) can modulate signaling pathways or gene expression profiles in a way that might affect MELK activity. The impact on MELK can arise from changes in the cellular environment, alterations in gene expression, or cross-talk between different signaling pathways.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, leading to increased cAMP levels, which can influence various kinases and potentially affect MELK signaling pathways. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which is involved in numerous signaling pathways and could indirectly affect MELK activity. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits GSK-3β, a kinase involved in various signaling pathways, potentially influencing MELK activity. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
Estrogen, through its receptors, can initiate signaling pathways that might intersect with those regulated by MELK. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid, via its receptors, can modulate various gene expressions and signaling pathways, potentially affecting MELK. | ||||||
Thymosin β4 | 77591-33-4 | sc-396076 sc-396076A | 1 mg 100 mg | $134.00 $7140.00 | ||
TGF-β activates TGF-β receptors, influencing multiple signaling pathways that might intersect with MELK regulation. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Vitamin D3, through the vitamin D receptor, can influence various cellular processes that might affect MELK activity. | ||||||