MEAF6 Activators

MEAF6 Activators are a collection of chemical compounds that are believed to influence the function of MEAF6, a protein critical in histone acetylation as part of the NuA4 histone acetyltransferase complex. Thesecompounds primarily work by modulating the acetylation state of proteins, given that histone acetylation is a key process that MEAF6 is involved in. Especially, many of these compounds, such as Trichostatin A and SAHA, function as inhibitors of histone deacetylases (HDACs). By inhibiting HDACs, these compounds enhance histone acetylation, which can potentially increase the functional activity of MEAF6.

On the other hand, compounds like Anacardic Acid, Garcinol, and C646 are histone acetyltransferase (HAT) inhibitors. While they generally reduce acetylation, they could cause a greater dependency on the remaining active HATs, such as the NuA4 complex that includes MEAF6, thereby indirectly enhancing its activity. Also, some compounds, like Nicotinamide, function by inhibiting specific proteins like SIRT1, which indirectly enhances histone acetylation and potentially the activity of MEAF6. Therefore, the primary biochemical pathways these compounds influence are those involving the acetylation and deacetylation of histones, with the ultimate result being the potential enhancement of MEAF6's functional activity.