MCJ Activators
The chemical class termed MCJ Activators encompasses compounds that can potentially modulate the activity or expression of the MCJ protein through indirect mechanisms. These chemicals predominantly target mitochondrial functions and cellular stress responses, pathways integral to MCJ's physiological role. Compounds like Resveratrol, Metformin, and Rapamycin act on sirtuins, AMPK, and mTOR, respectively, pathways that are crucial in regulating cellular metabolism and stress responses. Their modulation can create a cellular context that enhances or alters the function of MCJ. For example, Resveratrol, through SIRT1 activation, can influence cellular stress pathways, potentially upregulating MCJ in response to altered mitochondrial dynamics and stress signaling. Similarly, Metformin, by activating AMPK, impacts mitochondrial biogenesis and function, which could lead to changes in MCJ expression or activity in response to shifts in cellular energy metabolism.
Furthermore, the action of Rapamycin on mTOR signaling can have a cascading effect on mitochondrial dynamics and stress responses, potentially modulating MCJ's role in these processes. Glycolysis inhibitors like 2-Deoxy-D-glucose create an energy stress environment, which could drive changes in MCJ expression or activity as the cell adapts to altered energy states. Curcumin, with its wide-ranging effects on multiple pathways, including those related to cellular stress and mitochondrial function, could also indirectly modulate MCJ. Sulforaphane activates Nrf2, influencing oxidative stress response pathways, which may impact MCJ expression as part of the cellular response to oxidative stress. Similarly, Nicotinamide, by influencing NAD+ levels and sirtuin activity, could affect MCJ indirectly through altered mitochondrial dynamics and cellular stress responses. Compounds that induce mitochondrial dysfunction, such as Hydrogen Peroxide, Rotenone, Antimycin A, CCCP, and Oligomycin, also play a significant role. These compounds, by disrupting various aspects of mitochondrial function, can trigger cellular stress responses, potentially influencing MCJ expression or activity. The alteration in mitochondrial function and the subsequent cellular response to this dysfunction could lead to an upregulation or modulation of MCJ, reflecting its role in managing mitochondrial stress and maintaining cellular homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
A polyphenolic compound that activates SIRT1, a protein involved in cellular stress responses and mitochondrial function. SIRT1 activation can lead to a modulation of cellular stress pathways, potentially influencing MCJ expression or function as part of the cellular response to altered mitochondrial dynamics and stress signaling. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $77.00 | 2 | |
An AMPK activator, influencing cellular energy metabolism. By activating AMPK, Metformin can modulate mitochondrial function and biogenesis, potentially affecting MCJ expression or activity as part of the mitochondrial stress response and cellular metabolism regulation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor, affecting cell growth and metabolism. Rapamycin's inhibition of mTOR signaling can indirectly influence mitochondrial dynamics and stress responses, potentially impacting MCJ through alterations in cellular growth and energy signaling pathways. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $65.00 $210.00 | 26 | |
A glycolysis inhibitor, which can induce a cellular energy stress response. By inhibiting glycolysis, 2-Deoxy-D-glucose can alter cellular energy metabolism, potentially influencing MCJ expression or activity as part of the cellular adaptation to energy stress, affecting mitochondrial function. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
A natural compound known to modulate multiple signaling pathways, including those related to cellular stress and mitochondrial function. Curcumin's broad modulatory effects could indirectly influence MCJ expression or activity in response to altered mitochondrial dynamics and cellular stress signaling. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
A compound that activates Nrf2, a key regulator of cellular antioxidant responses. Nrf2 activation can lead to a modulation of oxidative stress response pathways, potentially influencing MCJ expression or activity as part of the cellular response to oxidative stress, with implications for mitochondrial function. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $43.00 $65.00 $200.00 $815.00 | 6 | |
A precursor of NAD+, which is involved in cellular metabolism and sirtuin activation. Increased NAD+ levels can modulate sirtuin activity, potentially affecting MCJ expression or function indirectly through altered mitochondrial dynamics and cellular stress responses. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $30.00 $60.00 $93.00 | 27 | |
A reactive oxygen species, often used experimentally to induce oxidative stress. Hydrogen peroxide's induction of oxidative stress can influence cellular antioxidant responses, potentially impacting MCJ expression or activity as part of the mitochondrial stress response. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $254.00 | 41 | |
An inhibitor of mitochondrial complex I, inducing mitochondrial dysfunction and cellular stress. Rotenone's impact on mitochondrial function can lead to changes in cellular stress responses, potentially affecting MCJ expression or activity in response to altered mitochondrial dynamics. | ||||||
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $54.00 $62.00 $1642.00 $4600.00 | 51 | |
An inhibitor of mitochondrial complex III, inducing mitochondrial dysfunction. Antimycin A's effect on mitochondrial function can alter cellular energy metabolism and stress responses, potentially influencing MCJ expression or activity as part of the cellular adaptation to mitochondrial stress. | ||||||