MaxiK Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Paxilline | 57186-25-1 | sc-3588 sc-3588A | 5 mg 25 mg | $258.00 $942.00 | 14 | |
Paxilline is a selective inhibitor of MaxiK channels, demonstrating a unique binding affinity that stabilizes the closed state of the channel. Its interaction with the channel's voltage-sensing domains alters gating kinetics, leading to prolonged channel inactivation. This compound exhibits distinct conformational dynamics, influencing ion selectivity and permeability. The intricate balance of hydrophobic and electrostatic interactions within its structure contributes to its specificity and efficacy in modulating channel activity. | ||||||
Iberiotoxin | 129203-60-7 | sc-3585 sc-3585A | 10 µg 100 µg | $275.00 $500.00 | 16 | |
Iberiotoxin is a potent blocker of MaxiK channels, characterized by its high affinity for the channel's pore region. It disrupts ion flow by binding to specific residues, effectively occluding the channel and preventing potassium ion passage. This interaction alters the channel's conformational state, leading to a significant impact on cellular excitability. The toxin's unique structural features facilitate selective binding, enhancing its effectiveness in modulating channel function. | ||||||
Penitrem A | 12627-35-9 | sc-200997 sc-200997A | 1 mg 5 mg | $79.00 $220.00 | 5 | |
Penitrem A is a selective inhibitor of MaxiK channels, exhibiting a unique mechanism of action through its interaction with the channel's voltage-sensing domains. By stabilizing the closed conformation of the channel, it effectively reduces potassium ion conductance. This compound's distinct binding affinity alters the kinetics of channel activation and inactivation, leading to prolonged depolarization in excitable cells. Its structural complexity contributes to its specificity, making it a valuable tool for studying ion channel dynamics. | ||||||
Charybdotoxin | 95751-30-7 | sc-200979 | 100 µg | $401.00 | 9 | |
Charybdotoxin is a potent blocker of MaxiK channels, characterized by its high affinity for the channel's pore region. This peptide disrupts potassium ion flow by binding to the channel and preventing its opening, thereby influencing cellular excitability. Its unique structure allows for specific interactions with the channel's amino acid residues, altering the gating kinetics and prolonging the duration of action potentials. This specificity makes it a significant subject for exploring ion channel regulation. | ||||||
NS-1619 | 153587-01-0 | sc-200986 | 5 mg | $133.00 | 2 | |
NS-1619 is a selective activator of MaxiK channels, enhancing potassium ion conductance through unique allosteric modulation. Its distinct molecular interactions promote channel opening by stabilizing the active conformation, thereby facilitating ion flow. The compound exhibits a rapid onset of action, influencing the kinetics of channel activation and deactivation. This modulation of ion transport dynamics plays a crucial role in cellular signaling pathways, highlighting its intricate behavior in ion channel physiology. | ||||||